摘要
目的探讨天津市塘沽地区发热伴出疹症性疾病(RFIs)病原谱构成。方法采用酶联免疫吸附试验(ELISA)对2009年9月—2010年5月塘沽传染病医院就诊的发热伴出疹性疾病患者急性期血清标本进行麻疹、风疹和水痘IgM抗体检测,咽拭标本采用RT-PCR方法分离病毒。结果 243份血清标本中麻疹IgM抗体阳性检出率为51.44%,风疹IgM抗体阳性检出率为5.76%,水痘IgM阳性检出率为4.12%,三者全部阴性者占38.27%。236份咽试标本中麻疹病毒核糖核酸(RNA)阳性62份,风疹病毒RNA阳性27份。塘沽地区RFIs病例主要为20岁以上成人发病,占总病例的87.65%。麻疹IgM抗体阳性病例中,无免疫史和不详者占92.80%,风疹和水痘IgM抗体阳性病例均无免疫史。结论目前,塘沽地区发热出疹性疾病以麻疹为主,发病以大年龄组人群为主,同时具有一定的风疹和水痘病例,积极推行疫苗接种是控制麻疹、风疹和水痘发病的主要策略。
[Objective]To study the pathogen spectrum of rash and fever illness（RFIs） in Tanggu area of Tianjin.[Methods]The method of ELISA was adopted to detect the IgM antibodies of measles,rubella and chickenpox in the serum of RFIs cases during acute stage in Tanggu infectious diseases hospital from September 2009 to May 2010.The viruses were isolated from oropharyngeal swabs by RT-PCR.[Results]Among 243 serum samples,the positive rates of IgM antibody in measles,rubella and chickenpox were 51.44%,5.76% and 4.12% respectively,and 38.27% were negative all for measles,rubella and chickenpox.Among 236 oropharyngeal swabs,62 samples were positive for measles virus RNA,and 27 samples were positive for rubella virus RNA.87.65% of the total cases in Tanggu area were adults over 20 years old.Among measles cases with positive IgM antibody,92.80% had no history or an uncertain history of vaccination.All of rubella and chickenpox cases with positive IgM antibody had no immunity history.[Conclusion]At present,RFIs in Tanggu area is dominated by measles,most of patients are adults,and there are a number of rubella cases and chickenpox cases.The active promotion of vaccination is the major strategy to control measles,rubella and chickenpox.
出处
《职业与健康》
CAS
2011年第3期310-311,共2页
Occupation and Health
基金
天津市塘沽科技兴区(项目编号:2009XQ12-09)
关键词
发热出疹性疾病
麻疹
风疹
水痘
监测
Rash and fever illness（RFIs）
Measles
Rubella
Chickenpox
Surveillance
