摘要
目的探讨泛福舒胶囊（细菌溶解产物胶囊）对中重度支气管扩张症患者的临床疗效。方法将127例中重度支气管扩张症患者随机分为治疗组和对照组；对照组在伴发感染时予抗感染、平喘等治疗，治疗组在此基础上加用泛福舒胶囊（细菌溶解产物胶囊），每口晨空腹口服7mg，连服10d，停20d，再连服10d，停20d，再连续10d。连续使用3个月为1个疗程；连用3个疗程，两组均观察9个月，评价治疗前后血气分析PaO2（mmHg）、SaO2（％），血清IgG、IgA水平变化，呼吸道再发感染率（％）、平均住院日数（天）以及细菌刷检培养阳性率（≥10 3cfu／ml）的变化。结果两组治疗前PaO2（mmHg）、SaO2（％）对比差异无显著性（P〉0．01），治疗后治疗组PaO2（mmHg）、SaO2（％）明显好于对照组（P〈0．01）；两组治疗前阻清IgG、IgA对比差异无显著性（P〉0．01），治疗后治疗组血清水平IgA较对照组有明显提高（P〈0．01），而血清中IgG两组无明显变化，均无统计学意义；治疗后呼吸道再发感染率（％），治疗组再发感染的机率明显少于对照组（P〈0．05）；治疗后平均住院日数（天）治疗组明显少于对照组（P〈0．05）；治疗后纤维支气管镜刷检检查，细菌刷检培养阳性率（≥10cfu／ml），治疗组的阳性率明显低于对照组（P〈0．05）。结论泛福舒胶囊（细菌溶解产物胶囊）能调节机体的免疫功能，提高呼吸道的抵抗力，有效改善中重度支气管扩张症患者的预后。
Objective To explor the curative effect of Broncho-Vaxom in patiens of severe and middle hronchiectasis.Methods Total 127 patiens were randomized to two groups, treatment group were receive treatment using Broneho-Vaxom, antibiotic and antasthmatic.Contrl group receive treatment only using antibiotic and antasthmatie .Results The difference of PaO2 （ mmHg ） and SaO2 （ % ） level before treatment was not significant between two groups（P〉0.01 ）. The level of PaO2（ mmHg ） and SaO2（ % ） of treatment group obviously risen up compared to control group （ P〈 0.01 ）. There were not significant deviation of IgG and IgA level in blood serum before treatment between two group,（P〉0.01 ）. The level of IgG and lgA of treatment group obviously risen up compared to control group （ P〈 0.01 ）. The case and probability of palindromia respiratory infection the same as hospital day were obviously lower compared to control group（ P〈0.05 ）. The positive rate of bacterial culture by BFS of treatment group was lower significantly compared to control group （ P〈 0.05 ）. Conclusion Broncho-Vaxom could regulate immunologic function of hody and enhance defence of airway, it can effectively improve the prognosis of severe and middle bronchiectasis patients .
出处
《国际医药卫生导报》
2011年第3期317-319,共3页
International Medicine and Health Guidance News
