摘要
目的:探讨空腹血糖(FBG)、餐后2h血糖(2hPBG)、血粘度水平在糖尿病视网膜病变(Diabetic retinopathy,DR)发生和发展中的临床意义。方法:对44例2型糖尿病患者及20名正常人进行FBG、2hPBG、血液流变学检测,应用眼底荧光血管造影(fluorescein fundus angiography,FFA)进行DR的诊断、分期。研究对象分为:对照组、非糖尿病视网膜病变(non diabeticretinopathy,NDR)组和非增殖性糖尿病视网膜病变(nonproliferative diabeticretinopathy,NPDR)组,NPDR组进一步分为DR-Ⅰ,DR-Ⅱ,DR-Ⅲ组。结果:NPDR组2hPBG高于NDR组,差异具有统计学意义(P<0.01)。FBG水平NPDR组与NDR组之间无差异(P>0.05);血流变全血高切还原粘度及全血低切还原粘度、血浆粘度、血沉K值、红细胞变性指数、红细胞刚性指数,NPDR组、NDR组与对照组(正常人)之间具有显著性差异,但NPDR组之间及NPDR组、NDR组两者之间无显著性差异。结论:DR的程度和进展与2hPBG水平、血流变学密切相关,FBG并不是一个控制糖尿病及其并发症的理想监测指标。
Objective： To study the clinical significance between fasting blood glucose （FBG）, 2h postprandial blood glucose（2hPBG）and hemorrheology in the occurrence and development of diabetic retinopathy（DR）. Methods： The subjects were divided into control, non diabetic retinopathy （NDR） and non proliferative diabetic retinopathy（NPDR） group which include DR-Ⅰ,DR-Ⅱ and DR-Ⅲ groups. FBG,2hPBG and hemorrheology of 44 patients with type 2 diabetes and 20 normal subjects were detected in which DR was diagnosed and staging by fluorescein fundus angiography （FFA）. Results： There was no difference in FBG among groups（P0.05）and the 2hPBG of NPDR group was higher than that of NDR and conrol group（P0.01）.The blood high sheer reduced viscosity,blood low shearreduced viscosity,plasma viscosity,equation K value of ESR in NPDR and NDR groups were higher than that of conrol gruop（P0.01）,but index of rigidity（IR）and deformability index（DI）of NPDR and NDR groups were lower than that of conrol（P0.01）. Conclusion： This study suggested that DR and its progression might be closely related to the 2hPBG and hemorrheology. FBG is not a desirable marker for controling diabetes mellitus and its complication.
出处
《甘肃医药》
2011年第2期70-73,共4页
Gansu Medical Journal
关键词
增殖性糖尿病视网膜病变
糖尿病
空腹血糖
餐后血糖
血流变
眼底荧光血管造影
nonproliferative diabetic retinopathy
diabetes mellitus
fasting blood glucose
2h postprandial blood glucose
fluorescein fundus angiography
