摘要
目的:丁丙诺啡,纳洛酮注射液使海洛因依赖者住院5天内清醒状态下完成快速脱毒治疗。方法:用丁丙诺啡,纳洛酮注射液进行快速脱毒为A组(30例),同期内,选择年龄、性别、滥用史、滥用方式、末周日滥用量基本一致者,采用纳洛酮冲击疗法者为B组(30例),按纳洛酮冲击疗法操作程序准备及用药。比较两组住院至冲击治疗时间,冲击治疗中反应及治疗后戒断症状,不良反应等。A组患者治疗前后进行血常规、肝功能、肾功能及心电图检查。结果:A组患者平均住院4天左右完成脱毒,较B组(平均2.4天)拖后1.6天完成脱毒。A组治疗时间,平均2小时,病人一直处于清醒状态,治疗期间各项生命体征平稳,正常。治疗后戒断症状,无不良反应较B组轻。治疗时间明显短于B组(P<0.01),对肝功能、肾功能、心电图没有明显影响,冲击成功率100%。结论:海洛因依赖者清醒状态下快速脱毒安全性更高、依从性更好、可操作性更强、戒断症状,不良反应更轻。是目前较好的快速脱毒方法,很有临床实用价值,值得临床推广应用。
Objective：The Buprenrphine and Naloxone fast detoxification therapy was given to heroin addicts, under the condition of clear-headed, within 5 days. Methods： 30 patients with the Buprenrphine and Naloxone fast detoxification therapy under condition of clear-headed （A group） ;The Control group（B group）, which had the same situation with A group were given Naloxone shock therapy.A group ware examinod by function of hear,liver, kidney and blood routine before and after of treatment.Results：A group the average from admission to treatment 4 days was longer than B group 2.4 days （P〈0.01）. A group the time of treatment was shorter than B group （P〈0.01） , A group had fast detoxification Therapy of Under Condition of clear-headed , life sign was normal, smoothly and steadily. After treatment withdranal symptom and side effects was. Weighter than B group （P〈0.01）.This therapy had no significant influence on the function of Heart Liver. Kidney. The cure rate of the therapy was 100% .Conclusion：This therapy is effective and much safer.The therapy may is worthy of clinical application.
出处
《中国药物滥用防治杂志》
CAS
2011年第1期13-17,共5页
Chinese Journal of Drug Abuse Prevention and Treatment
关键词
海洛因依赖
丁丙诺啡和纳洛酮注射液
清醒状态快速脱毒治疗
Heroin dependence
Buprenrphine
Naloxone
Fast detoxification therapy
Under Condition ofclear-headed
Heroin addicts
