摘要
目的:探讨抑郁症和糖尿病共病患者的临床特征及疗效。方法:将40例伴有糖尿病的抑郁症患者和40例单纯抑郁症患者分成共病组和抑郁组,使用汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)和社会功能缺陷筛选量表(SDSS)评定两组患者的临床表现和社会功能,使用选择性5-羟色胺再摄取抑制剂治疗12周再次评定。结果:入组及治疗12周时,共病组HAMD、HAMA及SDSS总分均显著高于抑郁组(P<0.05),入组时HAMD焦虑/躯体化、认知障碍、迟缓、绝望感等因子分显著高于抑郁组(P<0.05),治疗12周共病组的减分率显著低于抑郁组(P<0.05)。结论:抑郁症和糖尿病共病患者的抑郁及焦虑症状重、社会功能缺陷明显,治疗效果显著差于单纯抑郁症患者。
Objective： To explore clinical characteristics and curative effect between depression and depression comorbid with diabetes mellitus. Method：Patients with depression comorbid either with （n=40） or without （n=40） diabetes mellitus were enrolled in this study.Hamilton depression scale （HAMD）,Hamilton anxiety scale （HAMA） and the social disability screening schedule（SDSS） were used to evaluate the clinical characteristics and social functions at baseline and after 12 weeks treatment by SSRIs. Results：The patients with diabetes mellitus had higher total scores in HAMD,HAMA and SDSS at baseline and 12 weeks later （P0.05）,and higher scores on anxiety/somatization,cognitive,hopelessness and retardation of HAMD at baseline （P0.05）.The patients with diabetes mellitus showed less reduction rates than the patients without diabetes mellitus through 12 weeks treatment （P0.05）. Conclusion：The patients with major depressive disorder and diabetes mellitus had more severe symptoms and social function impairment,and less curative effect.
出处
《临床精神医学杂志》
2011年第1期33-35,共3页
Journal of Clinical Psychiatry
关键词
抑郁症
糖尿病
共病
depressive disorder
diabetes mellitus
comorbidity
