摘要
目的：了解西洋参二醇组皂甙（ＰＱＳ）作为心脏停搏液的添加剂对鼠心异位移植后心肌缺血再灌注损伤的保护作用。方法：以鼠心腹部异位移植模型为研究手段，以心肌细胞内钙含量及受体鼠血清中ＣＫ、ＣＫＭＢ活力为观察指标，以Ｓｔ．ＴｈｏｍａｓⅡ号心脏停搏液为对照组。结果：ＰＱＳ可降低移植心脏心肌细胞内钙含量，降低受体鼠血清中ＣＫ、ＣＫＭＢ活力。结论：ＰＱＳ抗缺血再灌注损伤的机理为钙拮抗剂样作用。
Objective:To understand the protective effect of panaxadial quinqueloium saponins(PQS)on the ischemic myocardial reperfusion injury as an additive agent in the cardioplegic solution after the heterotopic heart transplantation in rats.Methods:The heterotopic heart transplantation model of rats was used,the calcium content and activity of CK,CK-MB in the recepient rats were taken as the indices of observation.Results:PQS could reduce the calcium content of the transplanted heart in the myocardial cells and activity of CK,CK-MB in the recepient rats.Conclusion:The mechanism of PQS antagonizing ischemic reperfusion injury was the effect like calcium antagonist.
出处
《中国中西医结合外科杂志》
CAS
1999年第4期262-264,共3页
Chinese Journal of Surgery of Integrated Traditional and Western Medicine
关键词
西洋参
二醇组皂甙
缺血
再灌注损伤
心异位移植
panaxadial quinqueloium saponin
ischemic reperfusion injury
heterotopic heart transplantation in rats
