摘要
查尔酮类化合物是广泛存在于自然界中一种黄酮类化合物,具有抗癌、抗炎症、抗菌、抗寄生虫、抗病毒等生物活性,是一类很具有前途的药物模板。重点阐述了近年来查尔酮类化合物的抗癌、抗炎症活性以及构效关系研究进展。结果表明查尔酮类化合物药理活性广泛、安全、结构简单且制备方便,是一个良好的药物开发先导物。
Chalcone, which are abundant in plants as a class of flavonoids, are confirmed to possess a diverse array of pharmacological activities and considered as a promising template for drug design. The studying progress on anticancer, anti inflammatory activities of chalcone, and the structure-activity relationship（SAR）was summarized. The findings indicate that chalcone has widely pharmacology activity, safety, simple structure, preparation convenient, and is a kind of good primer for drug development.
出处
《中南林业科技大学学报》
CAS
CSCD
北大核心
2011年第2期95-99,共5页
Journal of Central South University of Forestry & Technology
基金
国家科技部"十一五"科技支撑计划重点项目(2006BAD18B0404)
教育部博士点基金(20094321110001)
湖南省教育厅重点项目(08A084)
湖南省科技计划项目(2007NK3119)
长沙市科技局重点项目(K0802109-21)
关键词
查尔酮
抗癌
抗炎症
构效关系
chalcone
anti-cancer
anti-inflammatory
structure-activity relationship（SAR）
