摘要
目的研究脑卒中后抑郁患者(PSD)的抑郁状态与神经功能缺损的相关性。方法选择62例发病在24 h以内的急性脑梗死患者,采用Zung抑郁自评量表(SDS)将62例患者分为单纯脑梗死组和PSD组,并进行汉密尔顿抑郁量表(Hamilton depression,HAMD)和斯堪的那维亚神经功能缺损评分量表(SSS)评定,并与正常对照组比较。结果确诊PSD患者27例(43.5%);入院第2、7、14天时,PSD患者HAMD评分均显著高于单纯脑梗死组(P<0.01);单纯脑梗死组及轻度PSD组患者SSS评分随观察时间延长呈先降低而后逐渐增高,且轻度PSD组患者SSS评分较单纯脑梗死组比较具有统计学意义(P<0.05),而中、重度PSD组患者SSS评分随观察时间延长而降低,单纯脑梗死组患者则显著增加(P<0.01);单纯脑梗死组患者及轻度PSD组患者HAMD及SSS评分结果无相关性(t=1.351,P>0.05),中重度PSD组患者HAMD及SSS评分结果具有相关性(t=1.894,P<0.05;t=3.638,P<0.01)。结论 PSD的发病率为43.7%;中、重度PSD患者的HAMD评分与神经功能缺损程度具有相关性。
Objective To investigate the relationship between the depressive status and neurological function impairments in post - stroke depressive （PSD） patients. Methods 62 patients suffering acute cerebral infarction, whose course was less than 24 hours, were divided into pure infarction group and PSD group according to the score of Zung self - rating depression scale （SDS）. All patients were investigated with Hamilton depression rating scale （ HAMD ） and Scandinavia stroke scale （SSS）, then compared with healthy controls. Results 27 patients （43.5%） were diagnosed as PSD. Scores of HAMD in PSD group were significantly higher than those in pure infarction group at the 2nd,7th and 14th day （P 〈 0.01 ）. The score of SSS in pure infarction group and mild PSD group decreased at the 2nd day, while increased at the 7th and 14th day. There was significant difference in score of SSS between mild PSD group and pure infarction group （P 〈 0.05 ）. Score of SSS in moderate and severe PSD groups decreased gradually with time passing, and there were significant differences when compared with pure infarction group （ P 〈 0.01 ）. In pure infarction group and the mild group,there was no significant correlation between score of HAMD and of SSS （t = 1. 351, P 〉 0.05）. However, there was significant correlation in moderate PSD group （ t = 1. 894, P 〈 0.05 ） and in severe PSD group （ t = 3.638 ,P 〈 0.01 ）. Conclusion The prevalence of PSD was 43.7% in patients with acute cerebral infarction. The depressive status of patients with moderate and severe PSD is related with neurological function impairments.
出处
《精神医学杂志》
2011年第1期37-39,共3页
Journal of Psychiatry
关键词
脑卒中
抑郁
神经功能缺损
Stroke Depression Neurological function impairment
