2Cohen J.The immunopathogenesis of sepsis.Nature,2002,420:885-891. 被引量：1
3Zeerleder S,Hack CE,Wuillemin WA.Disseminated intravascular coagulation in sepsis.Chest,2005,128:2864-2875. 被引量：1
4Slofstra SH,ten Cate H,Spek CA.Signal tansduction induced by activated protein C:no role in protection against sepsis? Trends Mol Med,2006,12:374-381. 被引量：1
5Cinel I,Dellinger RP.Advances in pathogenesis and management of sepsis.Curr Opin Infect Dis,2007,20:345-352. 被引量：1
6Esmon CT.The interactions between inflammation and coagulation.Br J Haematol,2005,131:417-430. 被引量：1
7Levi M,van der Poll T,Büller HR.Bidirectional relation between inflammation and coagulation.Circulation,2004,109:2698-2704. 被引量：1
8Warren HS,Suffredini AF,Eichacker PQ,et al.Risks and benefits of activated protein C treatment for severe sepsis.N Engl J Med,2002,347:1027-1030. 被引量：1
9Bernard GR,Vincent JL,Laterre PF,et al.Efficacy and safety of recombinant human activated protein C for severe sepsis.N Engl J Med,2001,344:699-709. 被引量：1
10Angus DC,Laterre PF,Helterbrand J,et al.The effect of drotrecogin alfa (activated) on long-term survival after severe sepsis.Crit Care Med,2004,32:2199-2206. 被引量：1
3Dellinger RP,Levy MM,Carlet JM,et al.Surviving sepsis campaign:international guidelines for management of severe sepsis and septic shock:2008.Crit Care Med,2008,36:296-327. 被引量：1
4Rice TW,Bernard GR.Therapeutic intervention and targets for sepsis.Annu Rev Med,2005,56:225-248. 被引量：1
5Esmon C.The protein C pathway.Crit Care Med,2000,28:S44-48. 被引量：1
6Grinnell BW,Joyce D.Recombinant human activated protein C:a system modulator of vascular function for treatment of severe sepsis.Crit Care Med,2001,29:S53-60. 被引量：1
7Carr J.The anti-inflammatory action of heparin:heparin as an antagonist to histamine,bradykinin and prostaglandin E1.Thromb Res,1979,16:507-516. 被引量：1
8Agarwal R,Gupta D.Anticoagulation in sepsis:is low-dose heparin as effective as activated protein C? Intensive Care Med,2005,31:1297-1298. 被引量：1
9Wang H,Bloom O,Zhang M,et al.HMG-1 as a late mediator of endotoxin lethality in mice.Science,1999,285:248-251. 被引量：1
10Cheng B,Xie G,Yao S,et al.Epide-miology of severe sepsis in critically ill surgical patients in ten university hospitals in China.Crit Care Med,2007,35:2538-2546. 被引量：1
