摘要
1引言内质网（endoplasmic reticulum,ER）是真核细胞中钙离子贮存库,也是调节蛋白质合成及合成后加工、折叠和聚集的场所,是一种重要的细胞器。近年来,在生物医学研究领域中出现了一个新概念-＂内质网应激＂（ER stress）,即：在饥饿。
Endoplasmic reticulum（ER）,as an important cellular organelle in eukaryotic cells,is destroyed and dysfunctional under harmful stimuli.The stimuli cause the ER stress response which even induces the cell apoptosis.Recent studies indicate that ER stress is closely related to the occurrence and development of the neurodegenerative disease,for instance,prion diseases.The pathogenic agent known as misfolded prion protein causes the imbalance of ER homeostasis and then induces the neuron apoptosis.This review will summarize the latest research progress of the relationship between ER stress and prion diseases.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2011年第1期196-199,共4页
Chinese Journal of Pathophysiology
关键词
内质网
内质网应激
朊病毒病
细胞凋亡
Endoplasmic reticulum
Endoplasmic reticulum stress
Prion diseases
Apoptosis
