摘要
采用被动性回避反应、主动性回避反应和水迷宫实验，观察六味地黄汤对快速老化模型小鼠ＳＡＭＰ８记忆获得和记忆保持能力、条件性回避反应能力和空间记忆能力等学习行为功能的影响。结果显示，ＳＡＭＰ８记忆获得和记忆保持能力、条件性回避反应能力及空间记忆能力均明显衰退，长期给予六味地黄汤可提高ＳＡＭＰ８记忆获得和记忆保持能力，改善其空间记忆能力并部分改善其条件性回避反应能力。
Cognitionenhancing effect of Liuwei Dihuang decoction(LW)on SAM was observed by using passive avoidance performance,shuttle box and water maze tests in the present paper.It was showed that memory registration and retention ability,spatial memory as well as conditioned avoid response were all greatly declined in SAMP8.However,chronic administration of LW to SAMP8 enhanced the memory registration and retention ability in passive avoidance performance, promoted the spatial memory ability in water maze test and partially improved the leaning behavior in conditioned avoidance performance.The present results suggested that chronic administration of LW significantly ameliorated agerelated decline of learning and memory ability in SAM.
出处
《中国实验方剂学杂志》
CAS
1999年第4期29-33,共5页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金
国家"九五"攀登计划预选项目
