摘要
目的回顾性分析近5 a本院收治的急性白血病(AL)患儿临床资料,探讨浓缩红细胞输注量与AL患儿骨髓完全缓解(CR)后出现骨髓幼稚细胞增生、骨髓复发的关系。方法按初次化疗CR后骨髓原始幼稚细胞分布情况将74例AL患儿分为3组:规律无事件完成化疗组(无事件组)、首次骨髓幼稚细胞增生后缓解组(增生组)与首次骨髓复发组(复发组)。应用SPSS 17.0统计软件进行单因素方差分析,并对患儿复发及增生后骨髓原始+幼稚细胞比例与患儿平均每次每公斤体质量浓缩红细胞输注量的关系行Pearson相关分析。结果 3组患儿每次每公斤体质量浓缩红细胞输注量比较,差异有统计学意义(F=4.774,P<0.05),复发组、增生组均较无事件组患儿输注浓缩红细胞明显增多,复发组亦较增生组明显增多。复发及增生后骨髓原始+幼稚细胞比例与患儿平均每次每公斤体质量浓缩红细胞输注量呈正相关(r=0.51,P<0.05)。结论浓缩红细胞输注可能是促使AL患儿出现骨髓幼稚细胞增生、骨髓复发的重要因素之一。
Objective To analyze the clinical features of childhood acute leukemia at the latest 5 years in the First Affiliated Hospital of Zhengzhou University,explore the relationship between packed red blood cells transfusion and bone marrow blast percentage increasing and bone marrow relapse after complete remission（CR）.Methods Seventy-four cases were divided into 3 groups named completion of chemotherapy without anything regularly（group without anything）,bone marrow blast percentage increased firstly and eased later（group blast）and bone marrow relapsed firstly（group relapsed）,aimed at the average per-kg packed red blood cells transfusion of children with One-Way Analysis of Variance and SPSS 17.0 software.The correlations of the marrow original and babyhood cells after relapse and blast and the average per-kg packed red blood cells transfusion of patients were analyzed with Pearson correlation analysis.Results The 3 groups were compared respectively with each others,and there were significantly differences（F=4.774,P0.05）.The average per-kg packed red blood cells transfusion of children in the 3 groups were more and more in turn,and there were positive relationships between marrow original and babyhood cells after relapsing and blast and the average per-kg packed red blood cells transfusion of children（r=0.51,P0.05）.Conclusions The packed red blood cells transfusion is an important factor to improve the bone marrow blast percentage increasing and bone marrow relapse of childhood acute leukemia.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2011年第3期196-197,219,共3页
Journal of Applied Clinical Pediatrics
关键词
白血病
急性
浓缩红细胞
骨髓幼稚细胞增生
骨髓复发
儿童
acute leukemia
packed red blood cells
bone marrow blasts percentage increasing
bone marrow relapse
child
