摘要
研究外源性重组大鼠白细胞介素-6对2型糖尿病大鼠造模成功率的影响,并探讨不同造模手段对糖尿病大鼠空腹血糖、血清IL-6、空腹胰岛素指数的影响。实验时先将SD大鼠分为2组高脂饮食饲养6周,6周后将所有大鼠禁食12h,第一组进行一次性腹腔注射链脲佐菌素,第二组进行外源性重组大鼠白细胞介素6与链脲佐菌素混合腹腔注射。结果表明:注射外源性IL-6会一定幅度降低建模成功率;不同造模手段对糖尿病大鼠空腹血糖指数都有明显升高,但对其胰岛素分泌功能的影响不大甚至没有;STZ注射造模后,大鼠血清IL-6指数有明显升高,但外源IL-6注射造模大鼠的血清IL-6指数变化程度不很明显。
Studies the influence of exogenous rrIL-6 on the modeling success ratio of type II diabetes rats and discusses the effects of different modeling means on DM rat FBG,serum IL-6 and FINS.SD rats are divided into two groups which are fed for 6 weeks with the hyper-lipid feedstuff and experience the 12 hours＇ fasting.The first group experiences a one-time injection of STZ.STZ and rrIL-6 are injected into the second group.The result shows that the injection of exogenous IL-6 will reduce modeling success ratio to some extend.FBG of DM rats is increased remarkably by various modeling which has a little effect on DM rats＇insulin secretion.After STZ injecting,the index of rats serum IL-6 increases significantly but varies little from exogenous IL-6 modeling.
出处
《湖南工业大学学报》
2010年第6期105-108,共4页
Journal of Hunan University of Technology
