摘要
目的探讨同时伴有糖尿病的抑郁症患者皮质醇分泌节律的特点,及其在抑郁症患者所发生的糖尿病病理机制中的意义。方法首次确诊糖尿病的抑郁症患者(病例组,n=30)测定8:00、16:00、24:00血浆皮质醇浓度,同时测定空腹血糖、糖负荷后2小时血糖,并与正常糖代谢的抑郁症患者(对照组,n=30)进行对照。结果 (1)病例组8:00、16:00、24:00血浆皮质醇浓度[分别为(607±269)nmol/L、(416±178)nmol/L、(376±264)nmol/L]显著高于对照组[分别为(485±178)nmol/L、(290±154)nmol/L、(173±117)nmol/L],差异有统计学意义(均P<0.05)。(2)病例组皮质醇分泌节律消失者为73.3%,显著高于对照组的46.7%(P<0.05)。(3)病例组8:00、24:00的血浆皮质醇浓度与空腹血糖值正相关(γ=0.338、0.418,均P<0.05)。结论与正常糖代谢功能的抑郁症患者相比,伴发糖尿病的抑郁患者血浆皮质醇水平更高、皮质醇分泌节律消失者更多,高皮质醇血症可能是抑郁患者中糖尿病发生的重要病因之一。
Objective To study the characteristics of diurnal rhythm of cortisol secretion in depression patients with diabetes.Methods Two groups including depressed patients with newly diagnosed diabetes（case group,n=30）,depressed patients with normal glucose metabolism（control group,n=30）,undertook the assessment of rhythm in cortisol secretion at 3 time points（8：00;16：00;24：00） and fasting plasma glucose,2h plasma glucose after 75g glucose loading measurement before administration.Results Plasma cortisol levels in case group at time points of 8：00;16：00;24：00 were significantly higher than those in control group,showing 607±269 vs 485±178 nmol/L,416±178 vs 290±154 nmol/L,376±264 vs 173±117 nmol/L,all P0.05.The loss of normal diurnal rhythm of cortisol secretion was significantly more in case group than that in control group（73.3%vs 46.7%,P0.05）.Plasma cortisol levels at 8：00;24：00 were positively correlated with fasting plasma glucose in case group（γ=0.338,0.418;both P0.05）.Conclusions Contrasting with controls,depressed patients with diabetes have higher plasma level and more abnormal rhythm of cortisol secretion,and this may play a very important role in the pathomechanism of diabetes in depression.
出处
《实验与检验医学》
CAS
2010年第6期552-554,共3页
Experimental and Laboratory Medicine
关键词
抑郁症
糖尿病
皮质醇
分泌节律
Depression
Diabetes
Cortisol
Rhythm of cortisol secretion
