摘要
目的探讨长期居住于青藏高原的高血压患者颈动脉硬化斑块形成的危险因素。方法 95例高原高血压患者分为颈动脉有斑块组、颈动脉无斑块组。均记录吸烟史、高血压史,测量体重、血压,计算体重指数、脉压差,测定血清CRP、TCH、LDL、HDL、TG、SOD、MDA、NO值并行统计学分析。结果颈动脉斑块组MDA(P<0.01)、LDL(P<0.01)、CRP(P<0.01)及脉压差(P<0.05)均较无斑块组明显升高,差异有显著性,SOD(P<0.05)与NO(P<0.01)下降明显,差异有统计学意义;Logistic回归分析提示,LDL、MDA为高原高血压患者颈动脉硬化斑块形成的主要危险因素,SOD为保护因素。结论长期居住于高原缺氧地区的高血压患者的氧化应激水平明显增高,其氧化应激水平的升高可能是诱发动脉硬化、冠心病及卒中等心血管疾病发生的主要风险因素。
Objective To explore the correlation factor of carotid atherosclerosis plaque in the patients with essential hypertension （EH） at plateau. Methods Serum CRP, TCH, LDL, HDL, TG, SOD, MDA and NO were detected in 95 cases of patients with EH including non - carotid atheroselerosis plaque and carotid atherosclerosis plaque . The physical examinations included determination of age, hypertension course, body mass index, blood pressure, pulse pressure, smoking history, etc. Results The levels of pulse pressure （ P 〈 0. 05 ）, CRP （ P 〈 0. 01）, LDL （ P 〈 0. 01） , MDA（P 〈0.01）in atherosclerosis plaque group were higher than those in nonatherosclerosis plaque group, SOD（ P 〈 0. 05 ） and NO （P 〈 0. 01 ）in atherosclerosis plaque group were lower than those in non - atherosclerosis plaque group. Stepwise regression analysis of relative factors for carotid atherosclerosis plaque showed that LDL, MDA and SOD were significantly associated with the carotid atherosclerosis plaque. So we considered that LDL and MDA were the risk factors and SOD was a protective factor. Conclusion Oxidative stress levels significantly increase in the patients with essential hypertension who live in plateau area for a long time, which may be one of the main risk factors of atheroselerosis, coronary heart disease and stroke in high altitude.
出处
《青海医学院学报》
CAS
2010年第4期242-245,共4页
Journal of Qinghai Medical College
基金
青海省科技能力建设计划项目(2009-Z-726)
关键词
高原缺氧
高血压
颈动脉硬化斑块
危险因素
氧化应激
High - altitude hypoxia Essential hypertension Carotid atherosclerosis plaque Risk factor Oxidative stress
