摘要
目的：观察卡培他滨单药治疗老年晚期胃癌的疗效和不良反应。方法：经病理证实的老年晚期胃癌。28例应用卡培他滨单药化疗,剂量为1 250 mg/m2,2次/d口服,治疗2周后停药1周,3周为1个周期。结果：共完成103个周期,最短1周期,最长8周期。18例可评价疗效,部分缓解（CR）4例,稳定（SD）11例,进展（PD）3例,有效率22.2%,疾病控制率83.3%。中位疾病进展时间（TTP）5个月,中位总生存（OS）7个月,一年生存率23.6%。不良反应主要为胃肠道反应和手足综合征,大部分为1~2级,耐受性好。结论：卡培他滨单药治疗老年晚期胃癌疗效肯定,毒副作用少。
Objective：To evaluate the efficacy and toxicity of capectiabine singal regimen for treatment of elderly patients with cancer of the stomach Methods：total of 28 cases with cancer of the stomach in the study,20 male and 8 female.The median age was 72 years old and ECOG performance ststus of 2-3.All patients received capecitabine 1 000 mg/m2,bid,d1-14.Results：Total 104 routines were finished.18 cases can be evaluated,4 partial responsed,and 9 stable cases were observed.The total response rate wse 22.2%.The medican time to progression was 5 month.The median overall survival was 8 month.The adverse events were gastric intestinal disorders and hand-food syndrome.Most of adverse events were gradeⅠorⅡ,and tolerated well.Conclusions：Capecitabine single regimen for the treztment of elderly patients with advanced or metastasis gastric cancer is effective and the toxicitites are tolerable.
出处
《航空航天医药》
2010年第12期2144-2146,共3页
Aerospace Medicine
关键词
卡培他滨单
老年胃癌
cancer of the stomach
capecitabine
elderly
