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不同镇痛方式对宫颈癌根治术患者应激反应的影响 被引量:1

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摘要 目的:比较硬膜外超前镇痛与术后硬膜外镇痛对宫颈癌根治术患者应激反应的影响。方法:择期拟行宫颈癌根治术的患者40例,ASAⅠ~Ⅱ级,随机分为术后硬膜外镇痛组(C组,n=20)和硬膜外超前镇痛组(P组,n=20),于L1~2间隙行连续硬膜外麻醉穿刺置管,P组在切皮前20min,而C组在术后待患者清醒、自主呼吸恢复拔除气管导管后,硬膜外注射0.5μg/ml舒芬太尼+0.15%罗哌卡因混合液12ml,30min后接镇痛泵,以4ml/h的速率硬膜外输注200ml。于硬膜外穿刺前(T0)、术后2h(T1)和8h(T2)时,采静脉血6ml,测定血浆促肾上腺皮质激素(ACTH)浓度和血清皮质醇(Cor)、C反应蛋白(CRP)的浓度。结果:与T0时相比,两组T1和T2时血清Cor、CRP的浓度和血浆ACTH浓度均升高(P<0.01);与C组相比,P组T1和T2时血清Cor、CRP的浓度和血浆ACTH浓度均降低(P<0.05)。结论:与术后镇痛相比较,硬膜外超前镇痛可以更好地抑制广泛全子宫切除术患者的应激反应。
出处 《中国当代医药》 2010年第36期72-72,75,共2页 China Modern Medicine
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参考文献7

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