摘要
目的观察沙利度胺(thalidomide)联合低剂量地塞米松治疗多发性骨髓瘤(MM)的疗效。方法 16例MM患者中9例为初治患者、7例为复发难治性患者。沙利度胺初始剂量为150mg/d,服用3～6个月。同时联合低剂量地塞米松10～20mg/d,d1-4,d9-12,d17-20,每月1个疗程。结果 CR3例,PR6例,PD3例,有效率为75%,NR4例。无不能耐受的副反应。结论沙利度胺联合低剂量地塞米松治疗初发和复发难治性老年多发性骨髓瘤安全有效。
Objective To observe the effectiveness of thalidomide combined with low dose dexamethasone on patients with multiple myeloma （MM）.Methods 16 cases with MM were enrolled for studies.Among them,9 cases are initial treament and 7 cases are relapsed or/ and refractory patient s.The dosage of thalidomide was 150mg/d,the administerd dosage of dexamethasone was 10～20 mg/dfor d 1-4 ,d 9-12 ,d 17-20 every month.Results Among the 16 evaluable patients,3 of them achieved complete remission （CR）,6 of them achieved partial remission （ PR）, 3 of them showed partial improving and 4 of them had no effects. Side effects could been tolerate.Conclusion Thalidomide Combined With Low Dose Dexamethasone might be effective in these patients with relapsed or/ and refractory MM,as well as these patients with initial treatment MM.
出处
《湖南中医药大学学报》
CAS
2010年第12期53-54,共2页
Journal of Hunan University of Chinese Medicine
