摘要
目的:观察缺血性修饰白蛋白(IMA)在急性心肌梗塞(AMI)溶栓前后峰值的变化及临床意义。方法:41例AMI溶栓患者均于溶栓前,溶栓后即刻、2h、4h、6h采血检测IMA;根据溶栓结果分为再通组(23例)和未再通组(18例),比较两组溶栓后IMA值及溶栓后IMA的峰值情况。并与32例健康者IMA值做比较。结果:AMI两组(再通组、未再通组)患者溶栓前IMA值均高于正常对照者[(69.015±2.818)U/ml:(68.718±3.224)U/ml:(45.444±3.541)U/ml,P<0.01];溶栓再通组患者IMA于溶栓后再次出现升高,于2h达到高峰,而未再通组IMA值呈逐渐下降趋势,再通组IMA值均显著高于未再通组(P均<0.01),分别为:溶栓后2h[(73.332±3.569)U/ml:(64.359±3.431)U/ml]、4h[(70.541±2.712)U/ml:(60.655±3.267)U/ml]、6h[(64.756±3.914 U/ml):(57.573±3.863)U/ml]。结论:缺血性修饰白蛋白有望成为提示心梗后溶栓再通的一个指标。
Objective：To investigate the change and clinical significance of ischemia-modified albumin（IMA） peak value in patients with acute myocardial infarction（AMI） treated by intravenous thrombolytic therapy.Methods：IMA was measured in 41 AMI patients before and 2h,4h,6h after thrombolytic therapy respectively.According to results of thrombolytic therapy,the patients were divided into recanalization group（n=23） and non-recanalization group（n=18）.IMA values and peak values of two groups after thrombolytic therapy were analyzed,and they were compared with those of 32 healthy controls.Results：IMA values of two groups of AMI patients were significantly higher than those of healthy controls before thrombolytic therapy [（69.015±2.818）U/ml vs.（68.718±3.224）U/ml vs.（45.444±3.541） U/ml,P〈0.01].IMA value of recanalization group increased again after thrombolytic therapy and reached peak at 2h,while that of non-recanalization group gradually decreased.IMA values of recanalization group were significantly higher than those of non-recanalization group after 2h [（73.332±3.569）U/ml vs.（64.359±3.431）U/ml],4h [（70.541±2.712） U/ml vs.（60.655±3.267） U/ml] and 6h [（64.756±3.914 U/ml） vs.（57.573±3.863） U/ml,P〈0.01 all] after thrombolytic therapy.Conclusion：The value of ischemia-modified albumin may become a index indicated recanalization after thrombolytic therapy in patients with myocardial infarction.
出处
《心血管康复医学杂志》
CAS
2010年第6期613-616,共4页
Chinese Journal of Cardiovascular Rehabilitation Medicine
关键词
白蛋白类
心肌梗塞
血栓溶解疗法
Albumins
Myocardial infarction
Thrombolytic therapy
