摘要
目的:研究应用聚乙二醇α-2a干扰素治疗后发生完全应答的HBV感染患者血清中γ干扰素(IFN-γ)和白细胞介素10(IL-10)变化的意义。方法:抽取应用聚乙二醇α-2a干扰素治疗发生完全应答HBV感染患者应答点及6个月后以及健康对照者、未进行治疗的HBV患者的静脉血,分离血清,检测血清中乙型肝炎病毒表面标志物(HBV-M)、乙型肝炎病毒核酸定量(HBV-DNA)、丙氨酸转移酶(ALT)以及血清中的IFN-γ和IL-10。结果:和未进行治疗的HBV患者相比,完全应答者血清中IFN-γ明显下降;和正常对照无明显差异,而IL-10在应答点6个月后发生下降,但仍高于正常对照。结论:应用聚乙二醇α-2a干扰素治疗有效清除病毒的同时,发生完全应答患者分泌IFN-γ的能力恢复正常,IL-10仍维持较高水平。有利于减轻炎症反应及肝脏组织的修复。
Objective：To study the change of IFN-γ and IL-10 in chronic HBV infection patients who whole responsed to pegylated interferon α-2a therapy.Methods：Separated the serum from the blood of HBV infected patients who whole responsed to pegylated interferon α-2a therapy or no therapy and health controls,tested the ALT, HBV-DNA,HBV-M of patients and the IFN-γ,IL-10 in the serum.Results：The IFN-γ in the serum lowered significantly compared to no therapy patients and had no difference with controls and IL-10 lowered in followed 6 month,but still higher than the health controls.Conelusioa：When pegylated interferon α-2a cleared HBV effectivly, the secretion of IFN-γ in whole responsed patients recovered normal and IL-10 remained highly which lessened the inflammation of liver and recovered liver tissure.
出处
《中国医药导刊》
2010年第12期2097-2099,共3页
Chinese Journal of Medicinal Guide
