摘要
目的对三七皂苷缓释微球(PNS-SRM)的理化性质进行研究。方法采用粒径测定、扫描电镜(SEM)、比表面积测定、差示扫描量热分析(DSC)、红外光谱(IR)、X射线衍射(XRD)、溶出度测定等手段研究PNS-SRM的理化性质。结果 PNS-SRM与物理混合物相比,在IR、DSC、XRD上有显著差异。PNS-SRM具有明显的缓释效应。结论 PNS-SRM中壳聚糖、丙烯酸树脂和三七皂甘(PNS)之间发生了分子间作用,有新晶形生成。
OBJECTIVE To study on physicochemical properties of Panax notoginseng saponins sustained release microspheres（PNS-SRM）.METHODS Some analytical methods,such as determination of particle size,scanning electron microscopy（SEM）,differential thermal analysis（DSC）,infrared spectra（IR）,X-ray powder diffraction（XRD）,specific surface area determination,dissolution test,were applied to the investigation of PNS-SRM.RESULTS There were difference between PNS-SRM and physical mixture in IR,DSC,XRD.The PNS-SRM had good slow releasing effect.CONCLUTION There is intermolecular interaction among chitosan,acrylic resin and PNS in PNS-SRM.In the PNS-SRM a new crystal form was generated.
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2010年第12期1112-1115,共4页
Chinese Journal of Modern Applied Pharmacy
基金
江西省卫生厅项目(2007A025)
江西省科技支撑计划(2008BB22500)
十一五重大新药创制项目(2009ZX09310-005)
关键词
三七皂苷
缓释微球
Panax notoginseng saponins
sustained release microspheres
