摘要
目的：探讨单用氯胺酮及氯胺酮联合丙泊酚用于小儿手术麻醉时对循环和呼吸系统的影响;副作用及术后苏醒情况.方法：选择100例小儿手术,随机分为A组50例,单用氯胺酮麻醉,B组50例,氯胺酮联合丙泊酚麻醉,观察两组术前、术中患儿血压（BP）、心率（HR）、呼吸频率（RR）、血氧饱和度（SPO2）变化;清醒时间及各种不良反应的发生情况.结果：A组麻醉5min后出现一过性血压升高、心率增快、轻度呼吸抑制和血氧饱和度下降,B组术中呼吸、循环情况相对稳定,两组SBP、HR、RR、SPO2差异有统计学意义（P〈0.05）;B组患者术后清醒时间短于A组（P〈 0.05）,头晕、恶心、呕吐等不良反应也明显少于A组（P〈0.05）.结论：氯胺酮复合丙泊酚用于小儿静脉全身麻醉明显优于氯胺酮单用于小儿静脉全身麻醉.
Objective： To investigate the single--ketamine and ketamine combined with propofol anesthesia in children when used for circulatory and respiratory systems; side effects and postoperative recovery situation. Methods： 100 cases of pediatric surgery, were randomly divided into A group of 50 patients, one with ketamine anesthesia, B group of 50 patients, propofol ketamine anesthesia, patients were observed before, during and children with blood pressure （BP）, heart rate （ HR）, respiratory rate （RR）, oxygen saturation （SPOz） change; awake all the time and the incidence of adverse reactions. Results： A group of anesthesia 5 min after a transient increase in blood pressure, heart rate, mild respiratory depression and decreased oxygen saturation, B group of respiration, circulation, relatively stable, two groups of SBP, HR, RR, SPOz difference was statistically significant （P〈0.05） ; B group patients recovery time shorter than the A group （P〈0.05）, dizziness, nausea, vomiting and other adverse reactions was less than A group （P〈0.05） ; Conclusion： Ketamine and propofol anesthesia for pediatric intravenous ketamine is better than a single intrave- nous anesthesia for children.
