摘要
目的探讨血管紧张素受体Ⅰ（angitotension Ⅱ type 1 receptor，AT1）在非小细胞肺癌（non-small cell lung Cancer，NSCLC）组织中的表达及其与临床和病理学特征的关系。方法采用用免疫纽织化学技术检测50例非小细胞肺癌组织中AT1R的表达。结果AT1在非小细胞肺癌细胞中不表达，而在肿瘤相关巨噬细胞中表达，阳性表达率为32．0％，在癌旁正常肺组织巨噬细胞中无表达。AT1在肺癌组织中的巨噬细胞的表达与年龄、性别、病理类型及分化程度无显著性差异（P均〉0．05），AT1表达与TNM分期、有无局部淋巴结转移有显著性差异（P〈0．05）结论研究结果提示血管紧张素受体Ⅰ可能参与巨噬细胞相关的肿瘤发展及血管生成过程，还可能与非小细胞肺癌预后有关联。
Objective： To investigate the expression ofangitotension Ⅱ type 1 receptor （AT1） in human non-small cell lung cancer and the correlation between AT1 expression in lung cancer and clinicopathological characteristics. Methods： The expression of AT1 were assessed by immunohistochemistry in 50 cases of NSCLC. Results： The expression of AT1 was localized in tumor-associated macrophages, whereas no clearly staining was found in lung cancer cells and macrophages in tumor lung tissues. The positive percentage of AT1 expression in tumor-associated macrophages was 32.0%. There was no significant relationship between AT 1 expression in macrophages and patients＇ age, sex, histology and differention （p〉0.05）. AT 1 expression in macrophages was associated with lymph node metastasis and TNM stage （p〈0.05） . Conclusion： The present findings suggest that ATl might participate in the process of macrophages-related tumor progress and angiogenesis, partly associated with the prognosis of NSCLC.
出处
《中国保健营养（下半月）》
2011年第1期231-233,共3页
China Health Care & Nutrition
关键词
血管紧张素受体Ⅰ
非小细胞肺癌
肿瘤相关巨噬细胞
免疫组织化学
angitotension Ⅱ type 1 receptor non-small cell lung cancer tumor-associated macrophages immunohistochemistry
