摘要
腺病毒载体是目前重要的基因转移载体之一。腺病毒可作为真核基因表达载体，可制成灭活、重组或抗癌疫苗用于预防呼吸道疾病、癌症和肝炎等传染病。在癌症的基因治疗方面，Ａｄ 载体可运载肿瘤抑制基因，自身基因编码蛋白能诱导细胞调亡，可作为前药物感染细胞，还能利用Ａｄ 的一些特殊复制子。
Adenoviral vectors have recently played an important role in gene transfer technology.Ad can use as eukaryotic gene expression vector,inactivated Ad vaccines reduce acute respiratory disease caused by Ad,recombinant Ad vaccines have been applied to cancer and viral diseases .The application of Ad vectors in cancer gene therapy have been demonstrated to be effective in carrying tumour suppression gene,Ad vextors can also produce a prodrug enzyme,and induce apoptosis and tumourical effects.
出处
《生物学杂志》
CAS
CSCD
1999年第5期28-29,共2页
Journal of Biology
关键词
腺病毒载体
载体
生物治疗
Human Adenoviral
Vectors
Biology Therapy
