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类胰高糖素肽-1及类似物在肥胖2型糖尿病治疗中的应用进展

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摘要 类胰高糖素肽-1（GLP-1）是由空肠、回肠和结肠内分泌细胞（L细胞）产生的目前已知作用最强的肠道促胰岛素分泌肽,近来发现它除刺激胰岛β细胞分泌胰岛素外,还具有促进β细胞再生、抑制食欲、调控β细胞基因特异表达等多种生物学效应。但由于其半衰期较短而限制了临床应用。类胰高糖素肽-1（GLP-1）类似物NN2211、Excendin-4克服了上述问题,延长了作用时间,为临床上治疗2型糖尿病提供了新的治疗手段。
作者 马本仲
机构地区 云南省昭通市第一人民医院神经内分泌科
出处 《中国误诊学杂志》 CAS 2011年第1期34-35,共2页 Chinese Journal of Misdiagnostics
关键词 糖尿病 Ⅱ型/药物疗法 人类 综述
分类号 R587.1 [医药卫生—内分泌]
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参考文献13

  • 1Deacon CF, Nauck MA, Nielsen MT,et al. Both subcutaneously and intravenously administered glucagon-like pepiede -1 are repidly degraded from the amino terminus in type Ⅱ diabetic patients and in heath subjects[J] . J Diabetes,1995,44:1126 -1131. 被引量：1
  • 2Hupe-Sodmann K, McGregor GP, Bribenbaugh R, et al. Charac terisation of the procesing by human neuttral endopeptidase 24. 11 of GLP-1 (7 -36) amide and comparison of the substrate specifi icty of the enzyme for other glucagon-like peptides[J]. Regul Pept, 1995,58 : 149-156. 被引量：1
  • 3Nathan DM, Schreiber E, Fogel H, et al. Insuliinotropic action of glucagon-like peptide-1 (7-37) indiabeticandnondiabeticsujects[J]. Diabetes Care,1992,15:270-276. 被引量：1
  • 4Thorens B. Expression cloning of the pancreatic βcell receptor for the gluco-ineretin hormone glucagon-like peptide 1 [J]. Proc Natl Acad Sci USA ,1992,89:8641-8645. 被引量：1
  • 5Widmann C, Dolci W, Thorens B. Internlization and homlologous desensitization of the GLP-1 receptor depend on phosphorylation of the receptor carboxyl tail at the same three sites[J]. Mol Endo- crinol, 1997,11 : 1094-1102. 被引量：1
  • 6Wang Y, Egan J M, Raygada M, et a l. Glucagon-like peptide-1 af- fects gene transcription and messenger ribonucleic acid stability of components of the insulin secretory system in RIN 1046-38 cell [J]. Endocrinology, 1995,136 :4910-4917. 被引量：1
  • 7牟波.胰升糖素样肽-1及其类似物的降糖机制研究进展[J].国外医学（内分泌学分册）,2003,23(B04):4-6. 被引量：10
  • 8Flint A,Raben A, Astrup A,et al. Glucagon-like peptide 1 pro- motes satiety and suppresses energy intake inhumans [J]. J Clin Invest,1998,101:515 -520. 被引量：1
  • 9Nauck MA, Kleine N, Orskou C, et al. Normalization of fasting hyperglycemia by exogenous glucagon-like peptide-1 (7-36) in type 2(non insulin-dependent)diabetic patients[J]. Diabetologia, 1993,36:741-744. 被引量：1
  • 10刘青,杨翰仪.治疗2型糖尿病新药胰高血糖素样肽-1的研究进展[J].白求恩医科大学学报,2001,27(1):103-104. 被引量：5

二级参考文献33

  • 1[1]Mojsov S,Heinrich G,Wilson IB,et al.Preproglucagon gene expression in pancreas and intestine diversifies at the level of posttranscriptional processing[J].J Biol Chem,1986,261:11880-11889. 被引量：1
  • 2[2]Bell GI,Santerre RF,Mullenbach GT.Hamster preproglucagon contains the sequence of glucagon and two related peptides[J].Nature,1983,302:716-718. 被引量：1
  • 3[3]Herrmaan C,Goke R,Richter G,et al.Glucagon-like peptide-1 and glucose-dependent insulin-releasing polypeptide plasma levels in response to nutrients[J].Digestion,1995,56:117-126. 被引量：1
  • 4[4]Schirra J,Katschinski M,Weidmann C,et al.Gastric emptying and releasing of incretin hormones after glucose ingestion in humans.[J].J Clin Invest,1996,97:92-103. 被引量：1
  • 5[5]Brubaker PL.Regulation of intestinal proglucagon-derived peptide secretion by intestinal regulatory peptides[J].Endocrinology,1991,128:3175-3182. 被引量：1
  • 6[6]Reberge JN,Brubaker PL.Regulation of intestinal proglucagon-derived peptide secretion by glucose-dependent insulinotropic peptide in a novel enteroendocrine loop[J].Endocrinology,1993,133(1):233-240. 被引量：1
  • 7[7]Nauck MA,Heimesaat MM,Orskov C,et al.Preserved incretin activity of glucagon-like peptide 1(7～36 amide)but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus[J].J Clin Invest,1993,91:301-307. 被引量：1
  • 8[8]Deacon CF,Nauck MA,Nielsen MT,et al.Both subcutaneously and intravenously administered glucagon-like peptide-1 are rapidly degraded from the amino terminus in type Ⅱ diabetic patients and in health subjects[J].Diabetes,1995,44:1126-1131. 被引量：1
  • 9[9]Hupe-Sodmann K,McGregor GP,Bribenbaugh R,et al.Characterisation of the processing by human neutral endopeptidase 24.11 of GLP-1 (7～36) amide and comparison of the substrate specificity of the enzyme for other glucagon-like peptides[J].Regul Pept,1995,58:149-156. 被引量：1
  • 10[10]Nathan DM,Schreiber E,Fogel H,et al.Insulinotropic action of glucagon-like peptide-1 (7～37) in diabetic and nondiabetic subjects[J].Diabetes Care,1992,15:270-276. 被引量：1

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中国误诊学杂志
2011年 第1期

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