摘要
目的探讨十一种常用抗生素在体外环境中对血清肿瘤标志物含量的影响。方法 50份肿瘤患者血清和20份正常血清中分别加入11种常用抗生素,采用免疫化学发光法检测AFP、CEA、CA125、CA153和CA199五种肿瘤标志物前后含量的变化,采用T检验进行统计学分析。结果加入青霉素钠、阿昔洛韦、乳酸环丙沙星氯化钠、头孢他啶、头孢呋辛钠、奥硝唑片、头孢拉啶后AFP检测值有差异(P<0.05);在加入乳酸环丙沙星氯化钠、头孢他啶、头孢呋辛钠、头孢拉啶、阿奇霉素磷酸二氢钠后CEA检测值有差异(P<0.05);在加入阿昔洛韦、头孢呋辛钠、头孢拉啶、亚胺培南西司他丁钠后CA125检测值有差异(P<0.05);在加入青霉素钠、头孢呋辛钠、哌拉西林钠舒巴坦钠(2∶1)、奥硝唑片、阿昔洛韦后CA199检测值有差异(P<0.05);在加入青霉素钠、头孢呋辛钠、哌拉西林钠舒巴坦钠(2∶1)、奥硝唑片、亚胺培南西司他丁钠、头孢他啶后CA153检测值有差异(P<0.05)。结论 11种常用抗生素除硫酸庆大霉素外,绝大多数对肿瘤标志物检测有影响,排除药物干扰因素对提高肿瘤标志物检测准确性具有临床意义。
Objective To discuss the effects of 11 commonly used antibiotics in vitro environment on the detection of serum tumor markers.Methods To select 50 samples of serum tumor markers and 20 normal serum samples respectively,and to join in the serum of eleven commonly used antibiotics,and to detect AFP,CEA,CA125,CA153 and CA199 five types of tumor markers before and after the content changes by chemiluminescence immunoassay and to analyse the result by using the t-test.Results Joined the penicillin lactic acid sodium,acyclovir,ciprofloxacin and sodium chloride,ceftazidime,cefuroxime sodium,ornidazole tablets,cephradine,the value of AFP was different after detection （P0.05）.Accession of chloride,ceftazidime,cefuroxime sodium,cephradine,azithromycin dihydrogen phosphate after CEA value differences（P0.05）.Joined acyclovir,cefuroxime sodium,cephradine,imide cilasatin sodium CA125 after testing was different（P0.05）.In joining the penicillin sodium,cefuroxime sodium,piperacillin sodium and sulbactam sodium（2∶1）,ornidazole tablets,acyclovir CA199 detection value when there was a difference（P0.05）.In joining the penicillin sodium,cefuroxime sodium,piperacillin sodium and sulbactam sodium（2∶1）,ornidazole films,polyimide cilasatin sodium,ceftazidime CA153 detection value after differences（P0.05）.Conclusion In most of the 11 commonly used antibiotics on tumor markers except gentamicin sulfate,they have clinical significance to improve the accuracy of tumor markers by exclude drug interference factors.
出处
《中国误诊学杂志》
CAS
2011年第1期18-20,共3页
Chinese Journal of Misdiagnostics
