摘要
目的观察血必净注射液对急性重症胰腺炎患者炎性介质的影响。方法将80例急性重症胰腺炎患者按病例尾号随机分为两组各40例，对照组在禁食、补液、抑酸、抗感染等治疗基础上，持续静脉泉入生长抑素6mg，乌司他丁20万U，连续治疗7d。治疗组在对照组治疗基础上静脉滴注血必净注射液，50ml／次，2次／d，连用7d。观察两组治疗前后血中前列环素（PGI2）、血栓素A2（TXA2）肿瘤坏死因子a（TNFa）、白介素1、6、8（IL-1、6、8）的变化。结果治疗后，与对照组比较，治疗组PGI2升高（4．70±0．49）、PGI2／TXA2升高（0．10±0．01），TXA2降低（48．20±13．22）、TNFa降低（28．00±1．30）、IL-1降低（35．60±3．20）、IL-6降低（52．20±8．70）、IL-8降低（26．10±3．80）。结论血必净注射液联合两医常规治疗，可抑制急性重症胰腺炎炎症因子的释放，控制炎症反应。
Objective To evaluate the effects of Xuebijing injection on inflammatory mediators of patients with severe acute pancreatitis. Methods Using double blind method, 80 cases with severe acute pancreatitis were randomly divided into two groups, with 40 cases in each group. The control group was treated with conventional therapy such as： fasting, fluid replacement, acid inhibition and anti-infection, combined with the continuing injection with the growth hormone release inhibiting 6 mg, ulinastatin 200000u for 7 days. Based on the control group＇s treatment, the other group was added with Xuebijing injection 50 ml, twice a day for 7 days. The plasma levels of prostaglandin 12 （PGI2）, thromboxane A2 （TXA2）, tumor necrosis factor a （TNFa）, interleukin-1,6,8 （IL-1,6,8） were compared before and after the treatment in each group and between two groups Results Compared with the control group, Xuebijing injection group had marked effects on modulating the levels of inflammatory mediators. The levels of PGI2 and PGI2/TXA2 were increased significantly and the levels ofTXA2, TNF2, IL-1,6 and 8 were deceased （P〈0.05） sharply after the treatment. Conclusion Combined with conventional western medicine therapy, Xuebijing injection has the effects of inhibiting and controlling the release of inflammatory mediators on patients with severe acute pancreatitis.
出处
《国际中医中药杂志》
2011年第2期104-106,共3页
International Journal of Traditional Chinese Medicine
关键词
血必净注射液
急性胰腺炎
炎性介质
Xuebijing injection： Acute pancreatitis
Inflammatory mediators
