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内源性大麻素受体1在大鼠胰腺组织中的表达及意义

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摘要 目的观察大麻素受体1(CB1)在胰腺组织内的表达情况,为进一步研究2型糖尿病发病机制提供依据。方法摘取成年大鼠的胰腺,制备冰冻切片,进行双重免疫荧光染色,通过激光扫描共聚焦显微镜观察胰腺组织中CB1表达情况。结果 CB1在胰腺组织中有表达,且主要表达于B细胞。结论 CB1在大鼠胰腺主要表达于B细胞,其可能通过影响B细胞功能参与2型糖尿病的发生、发展。
机构地区 深圳市福田医院
出处 《山东医药》 CAS 北大核心 2011年第3期28-29,共2页 Shandong Medical Journal
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