摘要
目的分析HBeAg阴性轻、中度慢性乙型肝炎临床特征。方法比较HBeAg阳性(119例)和阴性(21例)两组慢性乙型肝炎的HBV DNA载量、HBVM异常持续时间、年龄、ALT及AST水平,探讨两组患者临床特征的差异。结果 HBeAg阴性组年龄较阳性组平均高11.2岁(P<0.01);HBeAg阴性组HBVM异常持续时间较阳性组平均长4.1年(P<0.01)。HBeAg阳性组ALT和AST水平较阴性组略有增高。HBeAg阴性组血清HBV DNA载量较阳性组平均低1.86log10copies/ml(P<0.01)。结论 HBeAg阴性慢性乙型肝炎患者感染HBV时间长、年龄大,血清HBV DNA载量较阳性组低。血清HBV DNA载量的变化影响到每次发病的程度,HBeAg阳性组患者ALT水平及AST水平较阴性组有增高的趋势,发病的轻重与血清HBV DNA载量的高低有关。
Objective To analyze the clinical features of patients with HBeAg negative mild to moderate chronic hepatitispatients B（CHB）.Methods HBV DNA load,HBVM,ALT,AST and age were recorded and analyzed in CHB patients with HBeAg positive（group P,119 cases） and negative（group N,21 cases）.Results Average age in group N was 11.2 years old more than that in group P（P0.01）.Average period of positive HBVM in group N lasted for 4.1 years longer than that in group P（P0.01）.ALT and AST levels of group P were slightly higher than those of group N（P0.05）.HBV DNA load in group P was 1.86log10 copies/ml more than that in group N（P0.01）.Conclusion Compared with CHB patients with HBeAg positive,the patients with HBeAg negative have elder age,longer period of positive HBVM,lower HBV DNA load and lower ALT level.
出处
《江苏医药》
CAS
CSCD
北大核心
2011年第1期83-85,共3页
Jiangsu Medical Journal
