摘要
目的:探讨Bcl-2及增殖细胞核抗原(PCNA)对绝经后子宫肌瘤发病的影响因素,为绝经后非萎缩肌瘤的病因学研究提供一定依据。方法:应用免疫组化SP法检测117例绝经前后子宫肌瘤及其相应肌壁中Bcl-2和PCNA的表达情况。结果:(1)绝经前肌瘤组Bcl-2的阳性表达率高于绝经后肌瘤组(P<0.05);绝经前分泌期肌瘤组高于增生期肌瘤组,绝经后非萎缩肌瘤高于绝经后萎缩肌瘤(P<0.05)。(2)绝经前增生期肌瘤组及分泌期肌瘤组、绝经后非萎缩肌瘤组Bcl-2表达强度高于其相应肌壁(P<0.05);绝经后萎缩性肌瘤组Bcl-2的表达强度与其相应肌壁差异无统计学意义(P>0.05)。(3)绝经前肌瘤组PCNA阳性表达率高于绝经后肌瘤组(P<0.05);绝经后非萎缩肌瘤高于绝经后萎缩性肌瘤组(P<0.05)。(4)绝经前增生期肌瘤组及分泌期肌瘤、绝经后非萎缩肌瘤组PCNA表达强度均高于其相应肌壁(P<0.05);绝经后萎缩性肌瘤组PCNA表达强度与其相应肌壁差异无统计学意义(P>0.05)。结论:绝经后非萎缩肌瘤同萎缩性肌瘤具有不同的临床病理特征,与凋亡失调及细胞异常增殖有关。
Objective：To investigate the expression of Bcl-2 and proliferating cell nuclear antigen （PCNA） in postmenopausal leiomyoma. Methods：The expressions of Bcl-2 and PCNA were examined by immunohistochemical technique in 117 postmenopausal patients with leiomyoma. Results：（1）The positive expression rate of Bcl-2 was significantly lower in premenopausal leiomyoma group than that of postmenopausal leiomyoma group （P 0.05）.（2）The expression level of Bcl-2 was significantly higher in proliferative and secretory phase groups of premenopausal leiomyoma, and non-regressive group of postmenopausal leiomyoma than that of the corresponding myometrium （P 0.05）, but no significant difference between the regressive postmenopausal leiomyoma and the corresponding myometrium（P 0.05）. （3） The positive expression rate of PCNA was significantly higher in premenopausal leiomyoma than that in postmenopausal leiomyoma （P 0.05）. （4） The expression level of PCNA was significantly higher in proliferative and secretory phase group of premenopausal leiomyoma, and non-regressive group of postmenopausal leiomyoma than that of the corresponding myometrium （P 0.05）, but no significant difference between the regressive postmenopausal leiomyoma and the corresponding myometrium （P 0.05）. Conclusion：The results indicated that there were different clinical and pathological features between different types of leiomyomas.
出处
《天津医药》
CAS
北大核心
2011年第1期14-16,共3页
Tianjin Medical Journal
