摘要
目的探讨45岁以上老年前期及老年期甲状腺乳头状癌(PTC)组织中C-MET和PP60C-SRC蛋白表达及其临床意义。方法应用免疫组织化学染色法分别检测27例45岁以上老年前期及老年期PTC组织、31例45岁以下人群PTC组织和27例甲状腺良性病变(腺瘤和结节性甲状腺肿)组织C-MET和PP60SRC蛋白表达。结果 C-MET在PTC中表达阳性率:老年前期及老年组为96.3%,45岁以下组为74.2%,甲状腺良性病变组为33.3%,各组差异显著(均P<0.05)。PP60C-SRC在癌组织中表达阳性率:老年前期及老年组为66.7%,45岁以下组为64.5%,甲状腺良性病变组为18.5%,PTC组与甲状腺良性病变组差异显著(P<0.05),但不同年龄组PTC中PP60C-SRC表达差异无统计学意义。结论 C-MET和PP60C-SRC在PTC存在高表达,且C-MET随年龄的增加有表达上调的趋势。
Objective To investigate the expressions of C-MET and PP60C-SRC protein in the above 45 years old-elderly and preelderly with papillary thyroid carcinoma（PTC） and its clinical significance.Methods 27 cases of PTC（above 45 years old） and 31 cases of PTC（less than 45 years old） were selected to detect the expressions of C-MET and PP60C-SRC protein by immunohistochemistry,and 27 thyroid benign lesions were also detected as control.Results The positive rate of C-MET in group PTC（≥45 years）,PTC（45 years） and benign lesions were 96.3%,74.2%,33.3%,respectively.There was significant difference among three groups（P0.05）.The positive rate of PP60C-SRC in group PTC（≥45 years）,PTC（45 years） and benign lesions were 66.7%,64.5%,18.5%,respectively.There was significant difference between PTC and benign lesions（P0.05）,but no statistical difference between different age groups.Conclusions The abnormal expressions of C-MET and PP60C-SRC maybe play an important role in the growth and differentiation of PTC,and the expression level of C-MET has a ascending trend along with aging.
出处
《中国老年学杂志》
CAS
CSCD
北大核心
2011年第1期9-11,共3页
Chinese Journal of Gerontology
基金
上海市卫生局青年科研项目(2008Y081)
