摘要
目的:比较奎硫平与利培酮治疗脑器质性精神病的疗效和不良反应。方法:将符合入组条件的57例脑器质性精神病患者随机分成奎硫平组和利培酮组,给予对应的药物治疗,研究观察8周,用简明精神病量表(BPRS)和不良反应量表(TESS)评定疗效和不良反应,分别在治疗前和治疗第2、4、6、8周末各评定1次。结果:研究过程中脱落5例。两组治疗后BPRS评分均明显下降,与治疗前比较差别显著(P<0.05),两组间同期BPRS评分比较无差别(P>0.05),奎硫平组有效率为57.69%,与利培酮组(65.38%)比较差别无显著意义(P>0.05)。利培酮组不良反应发生率高于奎硫平组,锥体外系反应、吞咽困难和总的不良反应发生率,两组间差别显著(P<0.05)。结论:奎硫平与利培酮治疗脑器质性精神障碍疗效相当,不良反应更小。
To compare the efficacy and side effects of quetiapine and risperidone in the treatment of brain organic mental disorder. Methods：57patients of brain organic mental disorder were randomly assigned into quetia pine group and rlsperidone group,treated for 8 weeks. Efficacy and side effects were assessed with BPRS and TESS before treat- ment and at2, 4, 6, 8 weeks. Results： 5patients were missing. The scores of BPRS decreased significantly in both groups after treatment（ P 〈 0.05 ） , there were no significant difference between two groups at the same time（ P 〉 0.05 ）. The effective rate of quetiapine group was 57. 69%, risperidone group was 65.38% , there were no significant difference（P 〉 0.05 ）. The side effects of risperidone group were significantly higher than quetiapine group,there were significant difference in dysphasia and EPS （ P 〈 0. 05 ）. Conclusion- Quetiapine is an effective drug with low side effects in lrearing brain organic mental disorder.
关键词
奎硫平
利培酮
脑器质性精神病
Quetiapine Risperidone Brain or-ganic mental disorder
