摘要
(R)-邻氯扁桃酸是一种具有广泛用途的药物中间体和精细化工产品,主要用于抗血小板聚集药物氯吡格雷的合成,其制备方法主要包括不对称合成法和光学异构体拆分法。本文主要对(R)-邻氯扁桃酸的各种制备方法进行了介绍,并比较了不同制备技术的优缺点,最后对手性邻氯扁桃酸的催化合成前景进行了展望。
（R）-2-chloromandelic acid is one of the most important intermediates and fine chemicals with broad use.It can be used for the synthesis of clopidogrel,an anti-platelet drug that inhibits the ability of platelets to clump together as part of a blood clot.Presently,（R）-2-chloromandelic acid can be prepared by asymmetric synthesis and resolution of racemate.This review introduces various preparation methods of（R）-2-chloromandelic acid,and compares the advantages and disadvantages of these methods.The prospect of（R）-2-chloromandelic acid synthesis methods is also discussed.
出处
《化工进展》
EI
CAS
CSCD
北大核心
2011年第2期396-401,406,共7页
Chemical Industry and Engineering Progress
基金
国家863计划项目(2009AA02Z203)
关键词
邻氯扁桃酸
(R)-邻氯扁桃酸
不对称合成
拆分
racemic 2-chloromandelic acid
（R）-2-chloromandelic acid
asymmetric synthesis
resolution
