摘要
目的探究血清C-反应蛋白(CRP)在细菌感染性疾病中浓度的变化。方法采用免疫比浊法对428例细菌感染性疾病患者和55例病毒感染患者血清CRP浓度进行测定,同时常规测定红细胞沉降率(ESR)、白细胞(WBC)计数及中性粒细胞百分数。结果细菌感染性疾病患者血清CRP浓度明显高于健康对照组(P<0.01);急性细菌感染性疾病的患者血清CRP浓度明显高于慢性感染者(P<0.01);在细菌感染急性期ESR、WBC计数及中性粒细胞百分数变化与CRP浓度变化具有相关性,但不如CRP浓度升高敏感。而病毒感染患者血清CRP浓度升高不明显,与健康对照组比较差异无统计学意义(P>0.05)。结论 CRP测定有助于细菌感染性疾病的鉴别诊断,其敏感性、特异性优于传统项目。
Objective To explore the change of serum concentration of C-reactive protein （CRP） in bacterial infectious diseases. Methods Immunoturbidimetric assay was performed to detect the serum concentration of CRP in 428 patients with bacterial infection and 55 patients with viral infection. Erythrocyte sedimentation rate （ESR）, white blood cell count （WBC） and neutrophil percentage were also carried out at the same time. Results Serum levels of CRP in patients with bacterial infections were signifi- cantly higher than in the controls （P〈0. 01） ,and serum levels of CRP in patients with acute bacterial infections were also significantly higher than in patients with chronic bacterial infections （P〈0.01）. There was certain correlation of ESR, WBC count and neutrophil cell percentage with the concentration of CRP during the acute stage of bacterial infection. But the sensitivity of the three detections was lower than CRP. The increase of serum concentration of CRP in patients with viral infection was not obvious,and was with no statistical difference,compared with healthy controls （P〉0.05）. Conclusion The determination of CRP contributes to the differential diagnosis of bacterial infectious diseases, and the sensitivity and specificity of it are better than traditional detections.
出处
《国际检验医学杂志》
CAS
2010年第12期1373-1374,共2页
International Journal of Laboratory Medicine
关键词
C反应蛋白质
感染
疾病
急性时相蛋白
C-reactive protein
infection
disease
acute phase proteins
