摘要
目的探讨还原型谷胱甘肽(GSH)对恙虫病并发肝损害的治疗价值。方法将53例恙虫病并发肝功能损害的患者随机分为A组和B组,A组加用还原型谷胱甘肽1.2 g/d,1次/d,静脉滴注,B组不加用还原型谷胱甘肽,其他治疗方法两组相同,于治疗后测定谷丙转胺酶(ALT)、血清谷草转氨酶(AST)、血清碱性磷酸酶(ALP)、血清总胆红素(TBil),并观察临床病情。结果两组ALT、AST、ALP、TBil较治疗前均明显降低,(P<0.05),A组的ALT、AST好转率较B组的高(P<0.05)。结论还原型谷胱甘肽对恙虫病并发肝损害具有较好的治疗保护作用。
Objective To study the effect of reducted glutathioue（GSH） in scrub typhus pantients complicated liver function damage. Methods A total of 53 scrub typhus patients complicated with hepatic damage were randomly divided into two groups. Thirty patients were given GSH in a dose of 1.2 g/d through intravenous drip for 7 days as GSH group, and 23 pantients were not given GSH to serve as control group. The same treatment was given to both groups other than GSH. The liver function related items were determined. Results After the treatment, serum to- tal alanine aminotransferase （ ALT ）, aspartate aminotransferase （ AST）, plasma, alkaline phosphatase （ALP） and bilirubin （ TBil ） singnificantly decreased in two groups （ P 〈 0. 05 ）, but the decrease of alanine aminotransferase （ALT） and aspartate aminotransferase （AST） was more marked in GSH group （P 〈 0. 05）. Conclusion GSH has beneficial effects in protecting liver function in scrub typhus patients with liver damage.
出处
《中国临床新医学》
2010年第12期1226-1227,共2页
CHINESE JOURNAL OF NEW CLINICAL MEDICINE
