摘要
为探讨围绝经期女性冠心病患者的冠状动脉病变特点及其与雌激素水平的关系，对２６ 例围绝经期和３８ 例绝经期后女性急性心肌梗死患者的冠状动脉造影结果及血清雌二醇和血脂水平进行对比分析。结果发现，围绝经期女性急性心肌梗死患者的冠状动脉轻、中度狭窄及单支血管病变明显多于绝经期后女性急性心肌梗死患者（ Ｐ＜ ０ ．０１） ，其血清雌二醇及高密度脂蛋白胆固醇水平较正常对照者明显降低，但高于绝经期后女性急性心肌梗死患者（ Ｐ 均＜ ０ ．０１） ；而血清总胆固醇、甘油三酯及低密度脂蛋白胆固醇水平较正常对照者明显升高，但低于绝经期后女性急性心肌梗死患者（ Ｐ 均＜ ０ ．０１） 。结果提示，围绝经期女性冠心病患者的冠状动脉病变以轻、中度狭窄和单支血管病变为主，其血清雌激素水平降低幅度较小，脂代谢异常程度较轻。
Aim To study the characteristics of coronary lesions and the relation with serum estrogen level in perimenopausal women with coronary artery disease (CAD). Methods The coronary angiograms and the serum estradiol (E 2)and lipid levels were compared between 26 perimenopausal women and 38 postmenopausal women with acute myocardial infarction (AMI). Results There were more cases with mild to moderate coronary artery stenoses and single-vessel diseases in perimenopausal women patients than in postmenopausal ones (P<0.01). In perimenopausal women patients, the serum levels of E 2 and high density lipoprotein cholesterol (HDLC) were significantly lower than in normal control (P<0.01), but higher than in postmenopausal patients (P<0.01). And the serum levels of total cholesterol (TC),triglyceride (TG) and low density lipoprotein-cholesterol (LDLC) were significantly higher than in control (P<0.01), but lower than in postmenopausal patients (P<0.01). Conclusions The coronary lesions in perimenopausal women with CAD were characterized by mild to moderate stenoses and single-vessel diseases. Meanwhile, there were less decrease of serum estrogen level and less abnormality of lipid metabolization in this group of patients.
出处
《中国动脉硬化杂志》
CAS
CSCD
1999年第3期238-240,共3页
Chinese Journal of Arteriosclerosis
关键词
心肌梗死患者
冠心病
雌激素
女性
Premenopausel
Myocardial Infarction
Coronary Disease
Coronary Angiography
Coronary Vessls
Estrogens
Lipids
Patients
