摘要
目的进一步证实实验性腹主动脉狭窄大鼠左心室肥厚及卡托普利的作用。方法采用实验性腹主动脉银夹狭窄大鼠模型，观察左心室重量指数（ＬＶＭＩ），放免测定血浆血管紧张素Ⅱ（ＡｎｇⅢ）及左心室心肌局部 Ａｎｇ Ⅱ。结果模型组ＬＶＭＩ、血浆ＡｎｇⅡ、左心室心肌Ａｎｇ Ⅱ水平明显高于假手术组；卡托普利组ＬＶＭＩ、血浆Ａｎｇ Ⅱ、左心室心肌Ａｎｇ Ⅱ明显下降。结论使用腹主动脉银夹狭窄方法建立心脏后负荷增加的心肌肥厚动物模型是可靠的，卡托普利确有抗心肌肥厚的作用。
Objective To confirm the effects of captopril on left ventricular hypertrophy in rats with abdominal aortic stenosis. Methods Left ventricular mass index (LVMI), plasma angiotensin Ⅱ (Ang Ⅱ) and left ventricular cardiac angiotensin Ⅱ were measured in the rat model.Aug Ⅱ was measured by radioimmunoassay. Results LVMI,plasma Aug Ⅱ,cardiac Aug Ⅱ of model group increased (P <0. 001,vs control group),while LVMI,plasma Aug Ⅱ,cardiac Aug Ⅱ of captopril group decreased (P <0. 05,P<0. 01,P<0. 001 vs model group). Conclusion The animal model of cardiac hypertrophy in rats with abdominal aortic stenosis is reliable. The effect of captopril on anticardiac hypertrophy was confirmed.
出处
《中国微循环》
1999年第3期152-153,共2页
Journal of Chinese Microcirculation
