摘要
晚期糖基化终末产物受体是细胞表面模式识别受体,在Ⅰ型肺泡上皮细胞有丰富表达.近年研究表明急性肺损伤时,支气管肺泡灌洗液及血浆中晚期糖基化终末产物受体含量明显升高,且与肺损伤程度密切相关.另一方面,它与相应配体结合激活细胞内信号通路,参与急性肺损伤的炎症激活和放大过程.晚期糖基化终末产物受体将在判断急性肺损伤患者病情、预后、监测疗效方面发挥重要作用,并为急性肺损伤的治疗提供新的思路.
Receptor for advanced glycation end products （RAGE） are pattern recognition receptors of cell surface, abundantly expressed in type Ⅰ alveolar epithelial cells. Recent studies have shown that RAGE level increases in bronchoalveolar lavage fluid and serum in acute lung injury, which is closely related with the degree of lung injury. Otherwise, RAGE are involved in inflammation activation and amplification of acute lung injury through binding with the corresponding ligands. RAGE may play an important role in judging condition, prognosis, and monitoring efficacy in patients with acute lung injury,and provide a new way for the treatment of acute lung injury.
出处
《国际呼吸杂志》
2011年第2期139-142,共4页
International Journal of Respiration
