摘要
目的探讨参麦对大鼠失血性休克后早期炎症反应的抑制作用。方法将30只Wistar大鼠随机分为3组,每组10只,分别为对照组(A组)、失血性休克组(B组)和失血性休克参麦治疗组(C组)。采用ELISA法测定血清白细胞介素1β(IL-1β)、白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)含量;采用化学反应法测定过氧化物歧化酶(SOD)活性及丙二醛(MDA)含量。结果 B组血清IL-1β、IL-6、TNF-α及MDA含量均显著高于A组(P<0.01),SOD活性明显低于A组(P<0.01)。而C组与B组比较,血清IL-1β、IL-6、TNF-α及MDA含量显著降低(P<0.05),SOD活性显著升高(P<0.05)。结论参麦能有效抑制大鼠失血性休克后早期炎症因子的表达,增强SOD的活性,从而抑制大鼠休克后早期炎症反应。
Objective To investigate the effect of shenmai（SM） on serum levels of interleukin-1β（IL-1β）,IL-6,tumor necrosis factors（TNF-α）,malondialdehyde（MDA）,superoxide dismutase（SOD） after hemorrhagic shock in rats.Methods Thirty rats were selected and divided into three group randomly（n=10）,the control group（A）,hemorrhagic group（B） and hemorrhagic ＋SM group（C）.The serum levels of IL-1β,IL-6,TNF-α,MDA and SOD were determined by ELISA or chemical reaction method.Results Serum levels of IL-1β,IL-6,TNF-α,MDA,in group B were highter than those in group A,and the SOD level of group B was lower than those in group A（P〈0.01）.Serum levels of IL-1β,IL-6,TNF-α and MDA in group C were lower than those in group B,and the levels of SOD of group C were higher than those in group B（P〈0.05）.Conclusion Shenmai can inhibit the expression of inflammatory factors,and stimulate the action of SOD after hemorrhagic shock.
出处
《重庆医学》
CAS
CSCD
北大核心
2011年第1期12-13,共2页
Chongqing medicine
关键词
休克
出血性
炎症介导素类
参麦
shock
hemorrhagic
inflammation mediators
shenmai
