摘要
目的观察阿托伐他汀对急性脑梗死（ACI）患者血清超敏c-反应蛋白（hs—CRP）、白细胞介素-6（IL-6）、白细胞介素-10（IL-10）以及神经功能缺损的影响，探讨其抗炎作用机制。方法将90例ACI患者随机分为阿托伐他汀组45例和常规治疗组45例。阿托伐他汀组在常规治疗基础上加用阿托伐他汀20mg，每日1次，连服4周。治疗前后检测血清hs—CRP、IL-6和IL-10含量，并进行神经功能缺损程度评分（NDS）评定。另选同期健康查体正常者20例为正常对照组。结果ACI患者较健康对照组血清hs—CRP、IL-6显著升高，IL-10显著下降（P〈0．05）；两组ACI患者治疗前hs—CRP、IL-6和IL-10差异无统计学意义（P〉0．05），治疗4周后阿托伐他汀组hs—CRP、IL-6较常规治疗组明显下降，而IL-10明显升高（P〈0．05）。此外，阿托伐他汀组治疗后NDS评分较常规治疗组显著升高（P〈0．05）。结论ACI患者较健康者血清hs—CRP、IL-6水平升高，IL—10水平下降。阿托伐他汀能明显降低ACI患者血清hs—CRP、IL-6水平，升高血清IL—10水平，有助于ACI患者的神经功能恢复，具有减轻炎症反应的神经保护作用。
Objective To study the effect of atorvastatin on the level of serum high -sensitivity C - reactive protein （hs - CRP）, interleukin - 6 （ IL - 6 ）, interleukin - 10 （ IL - 10） and neurological deficits in patients with acute cerebral infartion （ACI）. Methods Ninety patients with ACI were randomly divided into the atorvastatin therapy group（ n =45 ） and the conventional therapy group （n = 45 ）. At the basic of conventional therapy, the atorvastatin therapy group was treated with atorvastatin 20 mg/d. Both groups were treated for 4 weeks. The levels of serum hs - CRP, IL - 6 and IL - 10 were measured and the scores of neurological deficit scores （NDS） were evaluated before and after treatment. A healthy control group which approximately matched the experimental group included 20 heahy people. Results The level of serum hs- CRP, IL-6 in ACI patients was higher than that in the control groups, IL- 10 in ACI patients was lower than that in the control groups（ P 〈0.05 ）. No difference of hs - CRP, IL -6 or IL - 10 was found between the atorvastatin groups and the control groups before treatment （ P 〉 0.05）. But the level of hs - CRP and IL - 6 in atorvastatin groups decreased after treatment compared with control groups （P 〈 0.05）. While the IL -10 in atorvastatin group increased after treatment （ P 〈0.05）. The NDS in atorvastatin groups increased after treatment compared with control groups （ P 〈 0.05）. Conclusions Atorvastatin can significantly decrease the level of serum hs - CRP and IL -6, and increase the level of serum IL - 10. It can promote the neurological fuction recovery in patients with ACI. Atorvastatin may have anti -inflammatory effects and neuroprotection role.
出处
《中国实用医刊》
2011年第2期25-26,29,共3页
Chinese Journal of Practical Medicine
