摘要
目的研究骨桥蛋白（OPN）在胃癌发生、发展过程中的变化及其与幽门螺杆菌（Hp）感染的关系，为胃癌的靶向治疗和根除幽门螺杆菌治疗提供理论依据。方法应用免疫组化SABC法测定OPN在40例慢性浅表性胃炎、40例慢性萎缩性胃炎、40例异型增生及80例胃癌组织中的表达，分析其在胃癌发生、发展过程中的变化规律，评价其与胃癌临床病理特征的关系以及OPN表达与Hp感染的关系。结果OPN在胃癌组织中高表达且与肿瘤分期、淋巴结转移、远处转移及分化程度相关，同时还发现OPN表达与Hp感染有相关性。结论OPN与胃癌的发展、转移、分化程度以及Hp感染有关，而与胃癌的发生无明显关系，Hp在促进胃癌发生、发展的过程中可能有OPN的参与。
Objective To study the relationship between the expression of osteopontin （OPN） and gastric cancer＇ s occurrence and development as well as Helicobaeter pylori infection to provide a theoretical basis for the targeted therapy of gastric cancer and eradication of Helicobacter. Methods We applied immunohistochemical SABC method to detect the expression of OPN in the 40 examples of chronic superficial gastritis, 40 examples of chronic atrophic gastritis, 40 examples of dysplasia and 80 examples of gastric cancer. To analyse its variation in genesis and development of gastric cancer, evaluate the relationship between OPN and Helicobacter pylori infection as well as clinicopathologi features of gastric cancer. Results The expression of OPN was higher in gastric cancer and correlating with staging of cancer, lymph node metastasis, distant place metastasis and the degree of differentiation, at the same time we discovered the expression of OPN was correlating with Helicohacter pylori infection. Conclusions OPN is correlating with development, metastasis, degree of differentiation of gastric cancer and Helicobacter pylori Infection, but has no obviously relationship with genesis of gastric cancer, OPN possibly participate in the process of Helicobacter pylori＇ s carcinogenesis.
出处
《中国实用医刊》
2011年第2期9-10,共2页
Chinese Journal of Practical Medicine
关键词
胃癌
骨桥蛋白
幽门螺杆菌
免疫组化
Gastric cancer
Osteopontin
Helicobacter pylori
Immunohistochemistry
