摘要
目的探讨不同的治疗方案对初诊2型糖尿病患者血糖控制及胰岛β细胞功能的影响。方法80例初诊2型糖尿病患者随机分为两组，每组40例，在饮食及运动的基础上，分别使用胰岛素或格列美脲治疗，疗程8周，对其治疗前后血糖控制情况及胰岛β细胞功能进行自身及组间比较。结果两组均有明显降糖效果，治疗前后空腹血糖（FBG）、餐后2h血糖（2hPBG）、糖化血红蛋白（HbA1c）均显著下降（P〈0．05），两组之间差异无统计学意义（P〉0．05）；两组治疗后餐后2hC肽（2hPCP）明显上升（P〈0．05），但空腹C肽（FCP）上升不明显，且两组之间差异无统计学意义（P〉0．05）。结论对初诊2型糖尿病患者使用格列美脲联合二甲双胍和／或阿卡波糖严格控制血糖与早期使用胰岛素一样可以改善胰岛β细胞功能，且患者依从性好，有望成为2型糖尿病患者有效而简便的治疗方案。
Objective To study the effects of glimepiride and short-term intensive therapy with insulin on plasma glucose and beta-cell function in newly diagnosed type 2 diabetic patients. Methods 80 newly diagnosed type 2 diabetic patients were divided into two groups of 40 patients each and randomly treated with insulin or gllmepiride plus mefformin for 8 weeks. The FBG ,2hPBG, HbA1 c, improvement of beta-cell function were measured before and after intensive therapy in each group. Results After the treatment, FBG, 2hPBG, HbA1 c were significantly decreased （ all P 〈 0. 001 ） in each group; FCP and 2hPCP were increased （ P 〈 0.05 ） in each group. Conclusion Glimepiride or short-term intensive therapy with insulin plus mefformin could effectively improve glycemic control and beta-cell function in newly diagnosed type 2 diabetic patients.
出处
《中国基层医药》
CAS
2010年第1期16-17,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
糖尿病
2型
格列美脲
胰岛素
胰岛Β细胞
Diabetes mellitus,type 2
Glimepiride
Insulin
Pancreatic beta-cell
