摘要
研究蝙蝠葛碱对氯化铯诱发家兔在体心脏早后除极及触发性心律失常的作用．方法：采用单向动作电位记录技术记录家兔在体心脏单向动作电位，用氯化铯诱发家兔心脏早后除极及触发性心律失常。结果：静脉注射氯化铯１－２ ｍｍｏｌ·ｋｇ－１后 ＭＡＰＡ降低，ＭＡＰＤ９０， ＱＲＳ和Ｒ－Ｒ间期明显延长．给氯化铯后３０ｓ左右出现早后除极，并由此触发室性早搏和室性心动过速，蝙蝠葛碱降低早后除极幅度和心律失常发生率，早后除极幅度对照组为５２％±５％，蝙蝠葛碱组为２６％±９％（Ｐ＜０．０５），心律失常发生率对照组为８０％，蝙蝠葛碱组为２８％（Ｐ＜０．０５）、结论：蝙蝠葛碱具有抗氯化铯所致早后除极及触发性心律失常作用。
AIM: To study the effect of dauricine on CsCl-induced early afterdepolarizations (EAD) and ventricular arrhythmias in rabbits. METHODS: Monophasic action potentials (MAP) of the left ventricle of the rabbit heart in situ were recorded with MAP recording technique. CsCl 1-2 mmol·kg-1 iv was used to induce EAD and ventricular arrhythmias. RESULTS: CsCl resulted in decrease of MAP amplitude (MAPA, P<0.05) and prolongation of MAP duration at 90% repolarization (MAPD90, P<0.01), QRS, and R-R duration (P<0.05) compared with those before CsCl in the dauricine and control group. CsCl injection induced EAD that appeared within about 30 s and disappeared 5-15 min thereafter. EAD always preceded ventricular arrhythmias including ventricular premature beats and paroxysmal ventricular tachycardia. The EAD amplitude (EADA) in the dauricine group (26%±9% of MAPA) was smaller than that in the control group (52%±5% of MAPA, P<0.05) and the incidence of arrhythmias in dauricine group (28%) was lower than that in control group (80%, P< 0.05). CONCLUSION: Dauricine exerted an antagonistic effect on EAD and suppressed triggered ventricular arrhythmias by decreasing EADA.
出处
《中国药理学报》
CSCD
1999年第6期513-516,共4页
Acta Pharmacologica Sinica
基金
Project supported by the National Natural Science Foundation of China,! No 30070834.
