摘要
采用灌胃和静脉注射2种给药途径,观察给药1次14 d内小鼠的急性毒性反应;应用人参皂苷C-K(100 mg/kg)复制小鼠肺水肿模型,观察肾上腺素受体阻断剂对其影响;应用肾上腺素复制小鼠肺水肿模型,观察肾上腺素受体阻断剂对其影响.结果表明人参皂苷C-K小鼠口服最大给药量为10.0 g/kg,人参皂苷C-K小鼠一次性尾静脉注射,LD50及95%置信区间为111.707 mg/kg(96.235～118.449 mg/kg),其动物死亡主要在5～30min内,主要表现为急性肺水肿的病理改变.100 mg/kg剂量的人参皂苷C-K可复制典型的小鼠急性肺水肿模型,与肾上腺素所致小鼠肺水肿类似.α-肾上腺素受体阻断剂可减轻人参皂苷C-K致肺水肿,β-肾上腺素受体阻断剂则可加重人参皂苷C-K致肺水肿.
Acute toxicity of ginsenoside compound K after intragastric administration and intravenous injection is investigated.Mice lung edema model is prepared by intravenous injection of ginsenoside compound K（100 mg/kg） and the effects of adrenoceptor blocking pharmacons are observed.Mice lung edema model is duplicated by adnephrin induction and the effects of adrenoceptor blocking pharmacons are observed.The results indicates that the maximum dose of ginsenoside compound K to mice by intragastric administration is 10.0 g/kg.The half lethal dose（LD50） with 95 % confidence interval of intravenous injection once to mice is 106.942 mg/kg（96.235-118.449 mg/kg）.The α-adrenoceptor blocking pharmacon can abate the lung edema induced by ginsenoside compound K while the β-adrenoceptor blocking pharmacon can aggravate it.The lung edema of mice induced by Ginsenoside compound K（100 mg/kg） is similar with that induced by adnephrin.
出处
《烟台大学学报（自然科学与工程版）》
CAS
北大核心
2011年第1期59-64,共6页
Journal of Yantai University(Natural Science and Engineering Edition)
基金
山东省科学仪器设备升级改造技术项目(2007GG10002026)
