摘要
目的分析法莫替丁致药物不良反应(ADR)的一般规律和特点,以利临床合理使用。方法检索1998年至2009年《中国期刊全文数据库》(CNKI)中法莫替丁致ADR文献和医院临床病例报告,进行统计、分析。结果共搜索到ADR报告47例。法莫替丁致ADR多发生于60岁以上患者,男性约多于女性;中枢神经系统损害位居首位(13例,27.66%),过敏反应次之(10例,21.28%);临床表现多样,严重者为过敏性休克。结论应特别关注老年患者,密切观察中枢神经系统损害的早期症状,并采取相应措施,避免不良后果的发生。
Objective To investigate the law and characteristics of adverse drug reactions（ADR） caused by famotidine.Methods To retrieve the ADR documents caused by famotidine from CNKI（1998 —2009） and the case reports of ADR related to famotidine in our hospital were collected for statistical analysis.Results Famotidine induced adverse reactions mainly occurred in elderly patients aged over 60 years,more men than women.There were 13 cases of central nervous system damage（27.66%）,which took the first place,followed by the allergic reactions taking the second place.The clinical features were various and anaphylactic shock was most serious.Conclusion Clinicians and pharmacists should give the special attention to the elderly patients and early symptoms of central nervous system damage in the application to early find ADR and take the corresponding measures for avoiding the occurrence of adverse consequences.
出处
《中国药业》
CAS
2011年第1期60-61,共2页
China Pharmaceuticals
