摘要
肝硬化是一种常见的慢性肝病,是多原因引起的肝脏损害,肝星状细胞(HSC)在肝硬化、肝纤维化病程中起关键作用。多种信号分子都能导致HSC的活化激活。近年来的研究发现,尽管不同病因导致肝病的发病机制不同,但肝纤维化发生的共同途径均是HSC。对HSC激活的多信号分子复杂网络系统的研究,可以为HSC的基因治疗提供系统的理论基础,从而使HSC的基因治疗具有高靶向性、高效性和低免疫原性,达到理想的肝纤维化治疗效果。
Cirrhosis is a common chronic liver disease caused by many factors.Hepatic stellate cell（HSC）plays a important role in cirrhosis and liver fibrosis.Many signaling molecules can lead to HBC activation.Recent studies show that the common pathway of liver fibrosis is mediated by HSC although various causes differ in the pathomechanism.The investigations into multiple signalling molecular network activating HSC serves as the theoretical foundation of gene therapy for HSC,with a high targetedness,high efficiency,and low immunogenicity,in aiming to achieve favorable therapeutic effects on liver fibrosis.
出处
《医学综述》
2010年第24期3699-3702,共4页
Medical Recapitulate
基金
青海大学附属医院中青年科研基金项目(ASRF-2009-14)
关键词
肝硬化
肝星状细胞
信号分子
Cirrhosis
Hepatic stellate cells
Signal molecule
