期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

基质细胞衍生因子1在胃腺癌组织中的表达及其与微血管密度的关系 被引量：1

原文传递
导出
摘要 目的研究基质细胞衍生因子1(SDF-1)在胃腺癌组织中的表达,分析其与相关临床病理指标的关系及其与微血管密度(MVD)的关系,探讨肿瘤细胞SDF-1的表达对胃癌生长和转移、肿瘤血管生成的影响。方法采用免疫组织化学方法检测胃癌组织中SDF-1的表达,同时免疫标记CD34,检测胃腺癌组织中MVD。结果 58例胃腺癌组织中肿瘤细胞SDF-1表达显示低分化、有淋巴结转移、有浆膜侵犯明显高于高分化、无淋巴结转移、无浆膜侵犯,与淋巴结转移、组织学分级、浆膜侵犯、临床分期等临床病理参数呈正相关(P<0.05),而肿瘤细胞SDF-1表达与患者性别、年龄、肿瘤大小无关(P>0.05);肿瘤细胞SDF-1表达与胃癌组织中MVD呈正相关。结论 SDF-1可能通过促进肿瘤的血管形成而参与胃癌的浸润转移,影响胃癌患者预后;肿瘤组织表达SDF-1在胃癌生长、浸润、转移中发挥着重要作用。
作者 陈友权 于燕妮
机构地区 贵阳医学院病理教研室 安徽省六安市第二人民医院病理科
出处 《中华临床医师杂志（电子版）》 CAS 2010年第12期118-121,共4页 Chinese Journal of Clinicians(Electronic Edition)
基金 贵州省优秀科技教育人才省长专项资金[黔省专合字(2005)165号]
关键词 趋化因子CXCL12 腺癌 胃 微血管密度
分类号 R735.2 [医药卫生—肿瘤]
  • 相关文献

参考文献20

  • 1Parkin DM.International variation.Oncogene,2004,23(38):6329-6340. 被引量：1
  • 2Müller A,Homey B,Soto H,et al.Involvement of chemokine receptors in breast cancer metastasis.Nature,2001,410(6824):50-56. 被引量：1
  • 3Sun YX,Fang M,Wang J,et al.Expression and activation of alpha v beta 3 integrins by SDF-1 /CXC12 increases the aggressiveness of prostate cancer cells.Prostate,2007,67(1):61-73. 被引量：1
  • 4Iwasa S,Yanagawa T,Fan J,et al.Expression of CXCR4 and its ligand SDF-1 in intestinal-type gastric cancer is associated with lymph node and liver metastasis.Anticancer Res,2009,29(11):4751-4758. 被引量：1
  • 5Zou W,Machelon V,Coulomb-L′Hermin A,et al.Stromal-derived factor-1 in human tumors recruits and alters the function of plasmacytoid precursor dendritic cells.Nat Med,2001,7(12):1339-1346. 被引量：1
  • 6沈晓燕,王绍海,梁铭霖,汪宏波,肖兰,王泽华.CXCR4及其配体SDF-1在宫颈癌转移中的作用及其机制研究[J].癌症,2008,27(10):1044-1049. 被引量：18
  • 7Wagner PL,Hyjek E,Vazquez MF,et al.CXCL12 and CXCR4 in adenocarcinoma of the lung:association with metastasis and survival.J Thorac Cardiovasc Surg,2009,137(3):615-621. 被引量：1
  • 8Aghi M,Cohen KS,Klein RJ,et al.Tumor stromal-derived factor-1 recruits vascular progenitors to mitotic neovasculature,where microenvironment influences their differentiated phenotypes.Cancer Res,2006,66(18):9054-9064. 被引量：1
  • 9Orimo A,Gupta PB,Sgroi DC,et al.Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1 /CXCL12 secretion.Cell,2005,121(3):335-348. 被引量：1
  • 10Kryczek I,Lange A,Mottram P,et al.CXCL12 and vascular endothelial growth factor synergistically induce neoangiogenesis in human ovarian cancers.Cancer Res,2005,65(2):465-472. 被引量：1

二级参考文献14

  • 1Seotton C J, Wilson J L, Milliken D, et al. Epithelial cancer cell migration: a role for chemokine receptors? [J]. Cancer Res, 2001,61(13):4961-4965. 被引量：1
  • 2Muller A, Homey B, Soto H, et al. Involvement of chemokine receptors in breast cancer metastasis [J]. Nature, 2001,410 (6824) :50-56. 被引量：1
  • 3Engl T, Relja B, Marian D, et al. CXCR4 chemokine receptor mediates prostate tumor cell adhesion through alpha5 and beta3 integrins [J ]. Neoplasia, 2006,8(4) : 290-301. 被引量：1
  • 4Peng S B, Peek V, Zhai Y, et al. Akt activation, but not extracellular signal-regulated kinase activation, is required for SDF- 1 alpha/CXCR4-mediated migration of epitheloid carcinoma cells [J]. Mol Cancer Res, 2005,3(4):227-236. 被引量：1
  • 5Zhang J P, Lu W G, Ye F, et al. Study on CXCR4/SDFlalpha axis in lymph node metastasis of cervical squamous cell carcinoma [J]. Int J Gynecol Cancer, 2007,17(2):478-483. 被引量：1
  • 6Yang Y C, Lee Z Y, Wu C C, et al. CXCR4 expression is associated with pelvie lymph node metastasis in cervical adenocareinoma [J]. Int J Gynecol Cancer, 2007,17(3) :676-686. 被引量：1
  • 7Vo H P, Lee M K, Crowe D L. alpha2 betal integrin signaling via the mitogen activated protein kinase pathway modulates retinoic acid-dependent tumor cell invasion and transcriptional downregulation of matrix metalloproteinase 9 activity [J]. Int J Oncol, 1998,13(6):1127-1134. 被引量：1
  • 8Balkwill F. The significance of cancer cell expression of the chemokine receptor CXCR4 [J].Semin Cancer Biol, 2004, 14 (3):171-179. 被引量：1
  • 9Zlotnik A. Involvement of chemokine receptors in organ-specific metastasis [J]. Contrib Microbiol, 2006, 13: 191-199. 被引量：1
  • 10Brand S, Dambacher J, Beigel F, et al. CXCR4 and CXCL12 are inversely expressed in colorectal cancer cells and modulate cancer cell migration, invasion and MMP-9 activation [J]. Exp Cell Res, 2005,310( 1 ) : 117-130. 被引量：1

共引文献17

同被引文献15

  • 1Bittoni A,Maccaroni E,Scartozzi M. Chemotherapy for locally advanced and metastatic gastric cancer:state of the art and future perspectives[J].European Review for Medical and Pharmacological Sciences,2010.309-314. 被引量：1
  • 2Murakami T,Yamamoto N. Role of CXCR4 in HIV infection and its potential as a therapeutic target[J].Future Microbiol,2010.1025-1039. 被引量：1
  • 3Otsuka S,Klimowicz AC,Kopciuk K. CXCR4 overexpression is associated with poor outcome in females diagnosed with stage Ⅳ non-small cell lung cancer[J].JOURNAL OF THORACIC ONCOLOGY,2011.1169-1178.PMID21623238. 被引量：1
  • 4Muller A,Homey B,Soto H. Involvement of chemokine receptors in breast cancer metastasis[J].Nature,2001,(6824):50-56.doi:10.1038/35065016. 被引量：1
  • 5O′Hayre M,Salanga CL,Kipps TJ. Elucidating the CXCL12/CXCR4 signaling network in chronic lymphocytic leukemia through phosphoproteomics analysis[J].PloS One,2010.e11716.doi:10.1371/journal.pone.0011716. 被引量：1
  • 6Ottaiano A,Franco R,Aiello Talamanca A. Over-expression of both CXC chemokine receptor 4 and vascular endothelial growth factor proteins predicts early distant relapse in stage Ⅱ-Ⅲ colorectal cancer patients[J].Clinical Cancer Research,2006,(9):2795-2803.doi:10.1158/1078-0432.CCR-05-2142. 被引量：1
  • 7Ishigami S,Natsugoe S,Okumura H. Clinical implication of CXCL12 expression in gastric cancer[J].Annals of Surgical Oncology,2007.3154-3158. 被引量：1
  • 8Yasumoto K,Koizumi K,Kawashima A. Role of the CXCL12/CXCR4 axis in peritoneal carcinomatosis of gastric cancer[J].Cancer Research,2006.2181-2187. 被引量：1
  • 9Lee HJ,Kim SW,Kim HY. Chemokine receptor CXCR4 expression,function,and clinical implications in gastric cancer[J].International Journal of Oncology,2009.473-480. 被引量：1
  • 10Pellegrino A,Ria R,Di Pietro G. Bone marrow endothelial cells in multiple myeloma secrete CXC-chemokines that mediate interactions with plasma cells[J].British Journal of Haematology,2005.248-256. 被引量：1

引证文献1

二级引证文献3

中华临床医师杂志（电子版）
2010年 第12期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部