摘要
目的:探讨硼替佐米序贯自体外周血干细胞移植治疗原发性浆细胞白血病的疗效。方法:报道2例经硼替佐米治疗达到完全缓解(CR)或非常好的部分缓解(VGPR),顺利进行自体外周血干细胞移植的原发性浆细胞白血病病例并复习相关文献。结果:硼替佐米对原发浆细胞白血病疗效显著,不影响干细胞动员与采集,联合自体周血干细胞移植,可有效提高患者生活质量。结论:硼替佐米联合化疗及自体移植可能会改善原发性浆细胞白血病的预后。
Objective：To investigate the efficacy of combination of bortezomib and autologous stem-cell transplantation in the management of primary plasma cell leukemia（PPCL） .Method：Two patients achieved complete remission or very good partial remission with bortezomib-containing chemotherapy followed by autologous peripheral blood stem cell transplantation.Result：Bortezomib demonstrates high potency in the treatment of PCL and does not impair the mobilization of peripheral blood stem cells for the autologous stem cell transplantation.The combination of bortezomib and ASCT is an effective management stratety for PCL.Conclusion：Bortezomib containing chemotherapy and autologous stem-cell transplantation may improve the outcome of PCL.
出处
《临床血液学杂志》
CAS
2010年第6期651-653,657,共4页
Journal of Clinical Hematology
关键词
原发性浆细胞白血病
硼替佐米
干细胞移植
primary plasma cell leukemia
bortezomib
stem-cell transplantation
