摘要
目的：分析胸腺肽（ＴＰ）对长期使用氢化可的松（ＨＣ）并致敏的小鼠免疫器官与免疫功能的影响。方法：１６只Ｃ５７ＢＬ小鼠随机分ＴＰ组、ＨＣ组与正常组。ＴＰ组与ＨＣ组小鼠肌肉注射ＨＣ０．５ｍｇ／ｄ２周，用Ｈｅｐ２细胞致敏。ＴＰ组腹腔注射（腹注）ＴＰ１０μｇ／ｄ，ＨＣ组腹注ＮＳ，共６ｄ。取胸腺和脾组织行光镜、电镜观察，测淋巴细胞毒试验、溶肿瘤细胞反应等指标。结果：ＴＰ能促ＨＣ致萎缩的胸腺、脾淋巴细胞增生，提高免疫活性细胞的细胞免疫及体液免疫功能。结论：ＴＰ能调整ＨＣ的免疫抑制作用，提高淋巴细胞免疫功能。
Objective:To analyse the effect of thymic peptides(TP) on immune organs and immune function of mice sensitized and under long term hydrocortisone(HC) administration.Methods:16 C 57 BL mice were divided into 3 groups:TP,HC and control group.TP and HC groups were injected intramusculary with 0.5 mg/d HC for two weeks and sensitized with Hep 2 cell.There,TP 10 μg/d was injected to TP group and NS to HC group intraperitoneally for six days.Thymus and spleen were taken for examination with light and electron microscope,cytotoxicity of lymphocyte and humoral immune response et al.Results:TP augmented lymphocytes proliferation of atrophic thymus and spleen,increased humoral and cellular immune response of immune competent cells.Conclusions:TP can adjust immunosuppression due to HC administration and improve immune function of lymphocyte.
出处
《蚌埠医学院学报》
CAS
1999年第1期3-4,F002,共3页
Journal of Bengbu Medical College
基金
安徽省教育委员会资助
