摘要
综述应激免疫抑制蛋白（ｉｍｍｕｎｏｓｕｐｐｒｅｓｉｖｅｐｒｏｔｅｉｎｏｆｓｔｒｅｓｓ，ＩＳＰＳ）的研究概况和进展。大鼠和小鼠在应激条件下，通过中枢神经系统的作用，由外周Ｔ淋巴细胞产生了一种大分子蛋白质，对某些免疫功能具有抑制作用。称之为应激免疫抑制蛋白。它具有以下两个特点，一是相对分子质量很大，不像是已知的细胞因子、干扰素、肽类激素、神经肽等。二是它的独特生成机制。它是在应激条件下，通过中枢神经系统的作用，再以交感神经为介导，通过释放去甲肾上腺素，在Ｔ淋巴细胞生成的。这种生成方式尚未见到类似的报道。
Under the conditions of stress an immunosuppressive protein
(immunosuppressive protein of stress, ISPS) was generated in T lymphocyte, which acted as an
immune suppressor. The generation of the protein was controlled by central nervous system
and mediated by peripheral sympathetic nerves. Both the large molecular weight, which is
much larger than interleukins, interferons, hormonal peptides, neuropeptides, etc., and the
conditions of the generation of the protein implied that this protein is potentially a recently
discovered protein. It may be a very important molecule that could be very important to our
understanding of the interaction between central nervous system and immune function.
出处
《北京医科大学学报》
CSCD
1999年第3期197-203,共7页
Journal of Peking University(Health Sciences)
关键词
T淋巴细胞
分泌
应激
免疫抑制蛋白
ISPS
T lymphocytes/secret Lymphocyte transformation/antag Immunosuppressive
protein of stress
